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RGPD5 | RANBP2-like and GRIP domain containing 5 (1765 aa) | |||
RTN2 | reticulon 2 (545 aa) | |||
NUMBL | numb homolog (Drosophila)-like; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of [...] (609 aa) | |||
RANBP2 | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB (3224 aa) | |||
RGPD8 | RANBP2-like and GRIP domain containing 8 (1765 aa) | |||
RANBP1 | RAN binding protein 1; Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane (201 aa) | |||
RGPD6 | RANBP2-like and GRIP domain containing 6 (1765 aa) | |||
NUMB | numb homolog (Drosophila) (651 aa) | |||
AMPH | amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (695 aa) | |||
RGPD2 | RANBP2-like and GRIP domain containing 2 (1756 aa) | |||
RGPD1 | RANBP2-like and GRIP domain containing 1 (1756 aa) | |||
SRL | sarcalumenin; May be involved in the regulation of calcium transport (473 aa) | |||
RGPD3 | RANBP2-like and GRIP domain containing 3 (1758 aa) | |||
RGPD4 | RANBP2-like and GRIP domain containing 4 (1758 aa) |