Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | TRIB3 | tribbles homolog 3 (Drosophila); Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the ’Thr-308’ phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display k [...] (358 aa) | ||
 | ZNF337 | zinc finger protein 337; May be involved in transcriptional regulation (751 aa) | ||
 | CSPP1 | centrosome and spindle pole associated protein 1; May play a role in cell-cycle-dependent microtubule organization (1221 aa) | ||
 | CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3; Required for maintenance of mitochondrial crista integrity and mitochondrial function. May act as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (227 aa) | ||
 | FEM1C | fem-1 homolog c (C. elegans); Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity) (617 aa) | ||
 | RPP25L | ribonuclease P/MRP 25kDa subunit-like; May be a component of ribonuclease P or MRP (163 aa) | ||
 | DPPA4 | developmental pluripotency associated 4; May be involved in the maintenance of active epigenetic status of target genes (By similarity). May inhibit differentiation of embryonic cells into a primitive ectoderm lineage (By similarity) (304 aa) | ||
 | ZNF564 | zinc finger protein 564; May be involved in transcriptional regulation (553 aa) | ||
 | HEYL | hairy/enhancer-of-split related with YRPW motif-like; Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5’-CACGTG-3’ (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 (328 aa) | ||
 | NPHP4 | nephronophthisis 4; Involved in the organization of apical junctions in kidney cells together with NPHP1 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity) (1426 aa) | ||
 | RPGR | retinitis pigmentosa GTPase regulator (1152 aa) | ||
 | MAGEB2 | melanoma antigen family B, 2; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex (319 aa) | ||
 | RPGRIP1 | retinitis pigmentosa GTPase regulator interacting protein 1; Essential for RPGR function and is also required for normal disk morphogenesis (By similarity) (1286 aa) | ||
 | IQCE | IQ motif containing E (695 aa) | ||
 | FAM74A2 | family with sequence similarity 74, member A2 (127 aa) | ||
 | CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (358 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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