node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APLP2 | MASP2 | ENSP00000263574 | ENSP00000383690 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | mannan-binding lectin serine peptidase 2 | 0.917 |
C2 | MASP1 | ENSP00000299367 | ENSP00000296280 | complement component 2 | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 0.658 |
C4A | CFB | ENSP00000396688 | ENSP00000416561 | complement component 4A (Rodgers blood group) | complement factor B | 0.648 |
C4A | MASP1 | ENSP00000396688 | ENSP00000296280 | complement component 4A (Rodgers blood group) | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 0.553 |
C4A | MASP2 | ENSP00000396688 | ENSP00000383690 | complement component 4A (Rodgers blood group) | mannan-binding lectin serine peptidase 2 | 0.965 |
C4A | SERPING1 | ENSP00000396688 | ENSP00000278407 | complement component 4A (Rodgers blood group) | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.664 |
C4B | CFB | ENSP00000415941 | ENSP00000416561 | complement component 4B (Chido blood group) | complement factor B | 0.695 |
C4B | FCN2 | ENSP00000415941 | ENSP00000291744 | complement component 4B (Chido blood group) | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region | 0.560 |
C4B | HP | ENSP00000415941 | ENSP00000348170 | complement component 4B (Chido blood group) | haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation [...] | 0.480 |
C4B | MASP1 | ENSP00000415941 | ENSP00000296280 | complement component 4B (Chido blood group) | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 0.934 |
C4B | MASP2 | ENSP00000415941 | ENSP00000383690 | complement component 4B (Chido blood group) | mannan-binding lectin serine peptidase 2 | 0.957 |
C4B | SERPING1 | ENSP00000415941 | ENSP00000278407 | complement component 4B (Chido blood group) | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.730 |
CFB | C4A | ENSP00000416561 | ENSP00000396688 | complement factor B | complement component 4A (Rodgers blood group) | 0.648 |
CFB | C4B | ENSP00000416561 | ENSP00000415941 | complement factor B | complement component 4B (Chido blood group) | 0.695 |
CFB | SERPING1 | ENSP00000416561 | ENSP00000278407 | complement factor B | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | 0.482 |
FCN2 | C4B | ENSP00000291744 | ENSP00000415941 | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region | complement component 4B (Chido blood group) | 0.560 |
FCN2 | MASP1 | ENSP00000291744 | ENSP00000296280 | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 0.997 |
FCN2 | MASP2 | ENSP00000291744 | ENSP00000383690 | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region | mannan-binding lectin serine peptidase 2 | 0.919 |
FCN2 | MBL2 | ENSP00000291744 | ENSP00000363079 | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region | mannose-binding lectin (protein C) 2, soluble; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA | 0.645 |
HP | C4B | ENSP00000348170 | ENSP00000415941 | haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation [...] | complement component 4B (Chido blood group) | 0.480 |