node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LMBRD1 | MMACHC | ENSP00000359609 | ENSP00000383840 | LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 0.966 |
LMBRD1 | MMADHC | ENSP00000359609 | ENSP00000301920 | LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 0.885 |
LMBRD1 | MTR | ENSP00000359609 | ENSP00000355536 | LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.812 |
LMBRD1 | MTRR | ENSP00000359609 | ENSP00000264668 | LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.802 |
LMBRD1 | UBC | ENSP00000359609 | ENSP00000344818 | LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | ubiquitin C | 0.483 |
MMACHC | LMBRD1 | ENSP00000383840 | ENSP00000359609 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | 0.966 |
MMACHC | MMADHC | ENSP00000383840 | ENSP00000301920 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 0.998 |
MMACHC | MTR | ENSP00000383840 | ENSP00000355536 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.973 |
MMACHC | MTRR | ENSP00000383840 | ENSP00000264668 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.948 |
MMADHC | LMBRD1 | ENSP00000301920 | ENSP00000359609 | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | 0.885 |
MMADHC | MMACHC | ENSP00000301920 | ENSP00000383840 | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 0.998 |
MMADHC | MTR | ENSP00000301920 | ENSP00000355536 | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.985 |
MMADHC | MTRR | ENSP00000301920 | ENSP00000264668 | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.974 |
MTR | LMBRD1 | ENSP00000355536 | ENSP00000359609 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | 0.812 |
MTR | MMACHC | ENSP00000355536 | ENSP00000383840 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 0.973 |
MTR | MMADHC | ENSP00000355536 | ENSP00000301920 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; Involved in cobalamin metabolism | 0.985 |
MTR | MTRR | ENSP00000355536 | ENSP00000264668 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | 0.988 |
MTR | UBC | ENSP00000355536 | ENSP00000344818 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | ubiquitin C | 0.924 |
MTRR | LMBRD1 | ENSP00000264668 | ENSP00000359609 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | LMBR1 domain containing 1; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | 0.802 |
MTRR | MMACHC | ENSP00000264668 | ENSP00000383840 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 0.948 |