Your Input:
|
||||
RRAS | related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton (218 aa) | |||
KRAS | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa) | |||
CACNB3 | calcium channel, voltage-dependent, beta 3 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting (484 aa) | |||
CACNG5 | calcium channel, voltage-dependent, gamma subunit 5; Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity) (275 aa) | |||
PRKCB | protein kinase C, beta (673 aa) | |||
HRAS | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa) | |||
RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) (797 aa) | |||
CACNB2 | calcium channel, voltage-dependent, beta 2 subunit (660 aa) | |||
CACNA1H | calcium channel, voltage-dependent, T type, alpha 1H subunit (2353 aa) | |||
RAP1A | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner (184 aa) | |||
CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity) (1091 aa) | |||
CACNA1G | calcium channel, voltage-dependent, T type, alpha 1G subunit (2377 aa) | |||
PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (1265 aa) | |||
CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (2506 aa) | |||
CACNA1S | calcium channel, voltage-dependent, L type, alpha 1S subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the ’high-voltage activated’ (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...] (1873 aa) | |||
CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however ins [...] (2313 aa) | |||
NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa) | |||
CACNA1B | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] (2340 aa) | |||
CACNA2D4 | calcium channel, voltage-dependent, alpha 2/delta subunit 4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel (1137 aa) | |||
CACNB1 | calcium channel, voltage-dependent, beta 1 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting (598 aa) | |||
RASGRP3 | RAS guanyl releasing protein 3 (calcium and DAG-regulated); Guanine nucleotide exchange factor (GEF) for Ras and Rap1 (690 aa) | |||
SOS1 | son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) (1333 aa) | |||
CACNA1I | calcium channel, voltage-dependent, T type, alpha 1I subunit (2223 aa) | |||
CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis (1150 aa) | |||
CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity) (1091 aa) | |||
CACNB4 | calcium channel, voltage-dependent, beta 4 subunit; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting (520 aa) |