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EHBP1L1 EHBP1L1 PARD3 PARD3 SPTBN4 SPTBN4 SPTBN5 SPTBN5 TAB2 TAB2 SPTA1 SPTA1 EHBP1 EHBP1 SPTBN1 SPTBN1 SPTBN2 SPTBN2 NKPD1 NKPD1 ACTN4 ACTN4 SPTAN1 SPTAN1 KIDINS220 KIDINS220 SPTB SPTB NLGN1 NLGN1 ACTN2 ACTN2 UTRN UTRN ACTN1 ACTN1 KCNU1 KCNU1 DMD DMD RFXANK RFXANK KCNMA1 KCNMA1 ANKRA2 ANKRA2 PDZRN4 PDZRN4 LNX1 LNX1 LNX2 LNX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ACTN4actinin, alpha 4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (911 aa)
KIDINS220kinase D-interacting substrate, 220kDa; Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during ne [...] (1771 aa)
SPTBN4spectrin, beta, non-erythrocytic 4 (2564 aa)
LNX1ligand of numb-protein X 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65 (By similarity) (728 aa)
EHBP1EH domain binding protein 1 (1231 aa)
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of ’Lys-63’- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at ’Thr-187’. Involved in heart development (693 aa)
ANKRA2ankyrin repeat, family A (RFXANK-like), 2; May facilitate endocytosis by linking megalin to components of the cytoskeleton or endocytic machinery (313 aa)
RFXANKregulatory factor X-associated ankyrin-containing protein; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes (260 aa)
SPTBN2spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton (2390 aa)
EHBP1L1EH domain binding protein 1-like 1 (1523 aa)
SPTBN5spectrin, beta, non-erythrocytic 5 (3674 aa)
NKPD1NTPase, KAP family P-loop domain containing 1 (832 aa)
LNX2ligand of numb-protein X 2 (690 aa)
SPTBN1spectrin, beta, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane (2364 aa)
NLGN1neuroligin 1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity) (823 aa)
DMDdystrophin (3685 aa)
ACTN2actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (894 aa)
UTRNutrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) (3433 aa)
SPTA1spectrin, alpha, erythrocytic 1 (elliptocytosis 2); Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2419 aa)
SPTAN1spectrin, alpha, non-erythrocytic 1 (2477 aa)
PARD3par-3 partitioning defective 3 homolog (C. elegans) (1356 aa)
SPTBspectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2328 aa)
ACTN1actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (914 aa)
KCNU1potassium channel, subfamily U, member 1; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+) (By similarity) (1149 aa)
PDZRN4PDZ domain containing ring finger 4 (1036 aa)
KCNMA1potassium large conductance calcium-activated channel, subfamily M, alpha member 1 (1219 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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