node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALM1 | CNGA1 | ENSP00000349467 | ENSP00000384264 | calmodulin 1 (phosphorylase kinase, delta) | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | 0.802 |
CALML3 | CNGA1 | ENSP00000315299 | ENSP00000384264 | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | 0.800 |
CALML5 | CNGA1 | ENSP00000369689 | ENSP00000384264 | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | 0.800 |
CALML6 | CNGA1 | ENSP00000304643 | ENSP00000384264 | calmodulin-like 6 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | 0.800 |
CNGA1 | CALM1 | ENSP00000384264 | ENSP00000349467 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | calmodulin 1 (phosphorylase kinase, delta) | 0.802 |
CNGA1 | CALML3 | ENSP00000384264 | ENSP00000315299 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | 0.800 |
CNGA1 | CALML5 | ENSP00000384264 | ENSP00000369689 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes | 0.800 |
CNGA1 | CALML6 | ENSP00000384264 | ENSP00000304643 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | calmodulin-like 6 | 0.800 |
CNGA1 | CNGB1 | ENSP00000384264 | ENSP00000251102 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | 0.964 |
CNGA1 | CNGB3 | ENSP00000384264 | ENSP00000316605 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | cyclic nucleotide gated channel beta 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical [...] | 0.474 |
CNGA1 | GNAT1 | ENSP00000384264 | ENSP00000232461 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase | 0.947 |
CNGA1 | GUCA1A | ENSP00000384264 | ENSP00000053469 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | guanylate cyclase activator 1A (retina); Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure | 0.957 |
CNGA1 | GUCA1B | ENSP00000384264 | ENSP00000230361 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | guanylate cyclase activator 1B (retina); Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure | 0.941 |
CNGA1 | GUCY2D | ENSP00000384264 | ENSP00000254854 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | 0.934 |
CNGA1 | GUCY2F | ENSP00000384264 | ENSP00000218006 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | guanylate cyclase 2F, retinal; Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | 0.924 |
CNGA1 | PDE6A | ENSP00000384264 | ENSP00000255266 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | phosphodiesterase 6A, cGMP-specific, rod, alpha; This protein participates in processes of transmission and amplification of the visual signal | 0.970 |
CNGA1 | PDE6B | ENSP00000384264 | ENSP00000420295 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme | 0.961 |
CNGA1 | PDE6G | ENSP00000384264 | ENSP00000328412 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | phosphodiesterase 6G, cGMP-specific, rod, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones | 0.941 |
CNGA1 | SLC24A1 | ENSP00000384264 | ENSP00000261892 | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | solute carrier family 24 (sodium/potassium/calcium exchanger), member 1; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.970 |
CNGB1 | CNGA1 | ENSP00000251102 | ENSP00000384264 | cyclic nucleotide gated channel beta 1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP | cyclic nucleotide gated channel alpha 1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors | 0.964 |