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TTPAL TTPAL CLVS2 CLVS2 ENSG00000249590 ENSG00000249590 RLBP1 RLBP1 SEC14L2 SEC14L2 SEC14L3 SEC14L3 SEC14L6 SEC14L6 TTPA TTPA PLD2 PLD2 PLD1 PLD1 CLVS1 CLVS1 SEC14L5 SEC14L5 NAP1L3 NAP1L3 SEC14L4 SEC14L4 SEC14L1 SEC14L1 ARFGAP1 ARFGAP1 NAP1L5 NAP1L5 UBC UBC ARL1 ARL1 UBB UBB NAP1L2 NAP1L2 DOLK DOLK CHKB CHKB NAP1L6 NAP1L6 NAP1L1 NAP1L1 NAP1L4 NAP1L4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SEC14L3SEC14-like 3 (S. cerevisiae); Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids (400 aa)
SEC14L5SEC14-like 5 (S. cerevisiae) (696 aa)
SEC14L4SEC14-like 4 (S. cerevisiae); Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids (406 aa)
TTPAtocopherol (alpha) transfer protein; Binds alpha-tocopherol and enhances its transfer between separate membranes (278 aa)
NAP1L1nucleosome assembly protein 1-like 1; May be involved in modulating chromatin formation and contribute to regulation of cell proliferation (391 aa)
ARL1ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (181 aa)
TTPALtocopherol (alpha) transfer protein-like; May act as a protein that binds a hydrophobic ligand (Potential) (342 aa)
PLD2phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) (933 aa)
RLBP1retinaldehyde binding protein 1; Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the ’visual cycle’ (317 aa)
CLVS2clavesin 2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (327 aa)
UBBubiquitin B (229 aa)
ARFGAP1ADP-ribosylation factor GTPase activating protein 1 (414 aa)
SEC14L2SEC14-like 2 (S. cerevisiae); Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (403 aa)
NAP1L5nucleosome assembly protein 1-like 5 (182 aa)
CLVS1clavesin 1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (354 aa)
PLD1phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) (1074 aa)
UBCubiquitin C (685 aa)
DOLKdolichol kinase; Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors (By similarity) (538 aa)
NAP1L3nucleosome assembly protein 1-like 3 (506 aa)
NAP1L2nucleosome assembly protein 1-like 2; Acidic protein which may be involved in interactions with other proteins or DNA (By similarity) (460 aa)
NAP1L6nucleosome assembly protein 1-like 6 (107 aa)
NAP1L4nucleosome assembly protein 1-like 4 (375 aa)
SEC14L1SEC14-like 1 (S. cerevisiae) (719 aa)
CHKBcholine kinase beta; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis (395 aa)
SEC14L6SEC14-like 6 (S. cerevisiae) (397 aa)
ENSG00000249590Uncharacterized protein (338 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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