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STRINGSTRING
GLRX5 GLRX5 GLRX3 GLRX3 BOLA2 BOLA2 BOLA2B BOLA2B WDR38 WDR38 TAF3 TAF3 ZGLP1 ZGLP1 WDR16 WDR16 WDR5 WDR5 WDR88 WDR88 JUND JUND JUNB JUNB ENSG00000259371 ENSG00000259371 TEP1 TEP1 JUN JUN ASH1L ASH1L RRP1 RRP1 NLE1 NLE1 APAF1 APAF1 NFYA NFYA WDR5B WDR5B PBRM1 PBRM1 WSB2 WSB2 RRP1B RRP1B WDR90 WDR90 PAFAH1B1 PAFAH1B1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
JUNDjun D proto-oncogene; Transcription factor binding AP-1 sites (347 aa)
TEP1telomerase-associated protein 1; Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity) (2627 aa)
WDR90WD repeat domain 90 (1748 aa)
JUNBjun B proto-oncogene; Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5’-TGA[CG]TCA-3’ (347 aa)
BOLA2BbolA homolog 2B (E. coli) (152 aa)
WSB2WD repeat and SOCS box containing 2; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (404 aa)
GLRX5glutaredoxin 5; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (157 aa)
WDR5BWD repeat domain 5B; May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex (By similarity) (330 aa)
GLRX3glutaredoxin 3; Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (335 aa)
BOLA2bolA homolog 2 (E. coli) (152 aa)
RRP1Bribosomal RNA processing 1 homolog B (S. cerevisiae) (758 aa)
WDR16WD repeat domain 16; May play an essential role in the growth or survival of hepatocellular carcinoma (HCC) (620 aa)
TAF3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (929 aa)
NFYAnuclear transcription factor Y, alpha; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes (347 aa)
WDR88WD repeat domain 88 (472 aa)
WDR5WD repeat domain 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at ’Lys-4’. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (334 aa)
JUNjun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (331 aa)
WDR38WD repeat domain 38 (314 aa)
ASH1Lash1 (absent, small, or homeotic)-like (Drosophila); Histone methyltransferase specifically methylating ’Lys- 36’ of histone H3 (H3K36me) (2964 aa)
PBRM1polybromo 1 (1582 aa)
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] (410 aa)
ZGLP1zinc finger, GATA-like protein 1; Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function (By similarity) (271 aa)
NLE1notchless homolog 1 (Drosophila) (485 aa)
RRP1ribosomal RNA processing 1 homolog (S. cerevisiae); Plays a critical role in the generation of 28S rRNA (461 aa)
APAF1apoptotic peptidase activating factor 1 (1248 aa)
ENSG00000259371Uncharacterized protein (276 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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