node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCC | NEO1 | ENSP00000389140 | ENSP00000261908 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues | 0.905 |
DCC | NTN1 | ENSP00000389140 | ENSP00000173229 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.999 |
DCC | NTN3 | ENSP00000389140 | ENSP00000293973 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity) | 0.894 |
DCC | NTN4 | ENSP00000389140 | ENSP00000340998 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | netrin 4 | 0.977 |
DCC | NTN5 | ENSP00000389140 | ENSP00000270235 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | netrin 5 | 0.798 |
DCC | NTNG1 | ENSP00000389140 | ENSP00000359085 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.819 |
DCC | NTNG2 | ENSP00000389140 | ENSP00000376921 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.800 |
DCC | UNC5A | ENSP00000389140 | ENSP00000332737 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | unc-5 homolog A (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand | 0.979 |
DCC | UNC5B | ENSP00000389140 | ENSP00000334329 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | unc-5 homolog B (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity | 0.984 |
DCC | UNC5C | ENSP00000389140 | ENSP00000406022 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.990 |
DCC | UNC5D | ENSP00000389140 | ENSP00000385143 | deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene | unc-5 homolog D (C. elegans); Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.975 |
FLRT1 | UNC5B | ENSP00000246841 | ENSP00000334329 | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling | unc-5 homolog B (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity | 0.402 |
FLRT3 | UNC5B | ENSP00000339912 | ENSP00000334329 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | unc-5 homolog B (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity | 0.759 |
FLRT3 | UNC5C | ENSP00000339912 | ENSP00000406022 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.759 |
FLRT3 | UNC5D | ENSP00000339912 | ENSP00000385143 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | unc-5 homolog D (C. elegans); Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) | 0.659 |
FNDC1 | NTN1 | ENSP00000297267 | ENSP00000173229 | fibronectin type III domain containing 1 | netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.803 |
FNDC1 | NTN3 | ENSP00000297267 | ENSP00000293973 | fibronectin type III domain containing 1 | netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity) | 0.798 |
FNDC1 | NTN5 | ENSP00000297267 | ENSP00000270235 | fibronectin type III domain containing 1 | netrin 5 | 0.798 |
FNDC1 | NTNG1 | ENSP00000297267 | ENSP00000359085 | fibronectin type III domain containing 1 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.819 |
FNDC1 | NTNG2 | ENSP00000297267 | ENSP00000376921 | fibronectin type III domain containing 1 | netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.798 |