node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IGLL1 | VPREB1 | ENSP00000329312 | ENSP00000385361 | immunoglobulin lambda-like polypeptide 1; Critical for B-cell development | pre-B lymphocyte 1; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation | 0.985 |
IGLL1 | VPREB3 | ENSP00000329312 | ENSP00000248948 | immunoglobulin lambda-like polypeptide 1; Critical for B-cell development | pre-B lymphocyte 3; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells | 0.760 |
LGALS1 | VPREB1 | ENSP00000215909 | ENSP00000385361 | lectin, galactoside-binding, soluble, 1; May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase | pre-B lymphocyte 1; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation | 0.663 |
SPI-B | SPIB | ENSP00000473233 | ENSP00000471921 | Spi-B transcription factor (Spi-1/PU.1 related), isoform CRA_a; Transcription factor Spi-B; cDNA FLJ57438, highly similar to Transcription factor Spi-B | Spi-B transcription factor (Spi-1/PU.1 related); Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5’-GAGGAA-3’) that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation | 0.573 |
SPI-B | VPREB1 | ENSP00000473233 | ENSP00000385361 | Spi-B transcription factor (Spi-1/PU.1 related), isoform CRA_a; Transcription factor Spi-B; cDNA FLJ57438, highly similar to Transcription factor Spi-B | pre-B lymphocyte 1; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation | 0.412 |
SPI1 | SPIB | ENSP00000227163 | ENSP00000471921 | spleen focus forming virus (SFFV) proviral integration oncogene spi1; Binds to the PU-box, a purine-rich DNA sequence (5’- GAGGAA-3’) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity) | Spi-B transcription factor (Spi-1/PU.1 related); Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5’-GAGGAA-3’) that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation | 0.621 |
SPIB | SPI-B | ENSP00000471921 | ENSP00000473233 | Spi-B transcription factor (Spi-1/PU.1 related); Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5’-GAGGAA-3’) that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation | Spi-B transcription factor (Spi-1/PU.1 related), isoform CRA_a; Transcription factor Spi-B; cDNA FLJ57438, highly similar to Transcription factor Spi-B | 0.573 |
SPIB | SPI1 | ENSP00000471921 | ENSP00000227163 | Spi-B transcription factor (Spi-1/PU.1 related); Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5’-GAGGAA-3’) that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation | spleen focus forming virus (SFFV) proviral integration oncogene spi1; Binds to the PU-box, a purine-rich DNA sequence (5’- GAGGAA-3’) that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B- cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity) | 0.621 |
VPREB1 | IGLL1 | ENSP00000385361 | ENSP00000329312 | pre-B lymphocyte 1; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation | immunoglobulin lambda-like polypeptide 1; Critical for B-cell development | 0.985 |
VPREB1 | LGALS1 | ENSP00000385361 | ENSP00000215909 | pre-B lymphocyte 1; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation | lectin, galactoside-binding, soluble, 1; May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase | 0.663 |
VPREB1 | SPI-B | ENSP00000385361 | ENSP00000473233 | pre-B lymphocyte 1; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation | Spi-B transcription factor (Spi-1/PU.1 related), isoform CRA_a; Transcription factor Spi-B; cDNA FLJ57438, highly similar to Transcription factor Spi-B | 0.412 |
VPREB1 | VPREB3 | ENSP00000385361 | ENSP00000248948 | pre-B lymphocyte 1; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation | pre-B lymphocyte 3; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells | 0.618 |
VPREB3 | IGLL1 | ENSP00000248948 | ENSP00000329312 | pre-B lymphocyte 3; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells | immunoglobulin lambda-like polypeptide 1; Critical for B-cell development | 0.760 |
VPREB3 | VPREB1 | ENSP00000248948 | ENSP00000385361 | pre-B lymphocyte 3; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells | pre-B lymphocyte 1; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation | 0.618 |