26 items (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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some 3D structure is known or predicted

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second shell of interactors

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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Your Input:
	CTSC	cathepsin C (463 aa)
	HLA-F	major histocompatibility complex, class I, F (442 aa)
	SCAP	SREBF chaperone; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the [...] (1279 aa)
	TRAPPC2L	trafficking protein particle complex 2-like; May play a role in vesicular transport from endoplasmic reticulum to Golgi (140 aa)
	TRAPPC1	trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi (145 aa)
	FOLR1	folate receptor 1 (adult); Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells (257 aa)
	SEC16B	SEC16 homolog B (S. cerevisiae); Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization (1060 aa)
	RAB1B	RAB1B, member RAS oncogene family; Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (201 aa)
	LMAN1L	lectin, mannose-binding, 1 like (526 aa)
	SEC13	SEC13 homolog (S. cerevisiae); Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (322 aa)
	MCFD2	multiple coagulation factor deficiency 2; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors (146 aa)
	COL7A1	collagen, type VII, alpha 1; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen (2944 aa)
	CD59	CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase (128 aa)
	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 (418 aa)
	APOA4	apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons (396 aa)
	F8	coagulation factor VIII, procoagulant component; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa (2351 aa)
	SEC23IP	SEC23 interacting protein; Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P) (1000 aa)
	HLA-DRB5	major histocompatibility complex, class II, DR beta 5 (266 aa)
	HLA-C	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) (366 aa)
	HLA-A	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity) (365 aa)
	HLA-DRA	major histocompatibility complex, class II, DR alpha (254 aa)
	SAR1B	SAR1 homolog B (S. cerevisiae); Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (198 aa)
	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1 (260 aa)
	HLA-B	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity) (362 aa)
	TRAPPC4	trafficking protein particle complex 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi (219 aa)
	B2M	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) (119 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA4	B2M	ENSP00000350425	ENSP00000452780	apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.906
APOA4	SAR1B	ENSP00000350425	ENSP00000385432	apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons	SAR1 homolog B (S. cerevisiae); Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex	0.943
APOA4	SERPINA1	ENSP00000350425	ENSP00000348068	apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.418
B2M	APOA4	ENSP00000452780	ENSP00000350425	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons	0.906
B2M	HLA-A	ENSP00000452780	ENSP00000366005	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.998
B2M	HLA-B	ENSP00000452780	ENSP00000399168	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.999
B2M	HLA-C	ENSP00000452780	ENSP00000365402	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.986
B2M	HLA-DRB5	ENSP00000452780	ENSP00000364114	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class II, DR beta 5	0.903
B2M	HLA-F	ENSP00000452780	ENSP00000259951	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	major histocompatibility complex, class I, F	0.691
B2M	SAR1B	ENSP00000452780	ENSP00000385432	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	SAR1 homolog B (S. cerevisiae); Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex	0.901
B2M	SEC13	ENSP00000452780	ENSP00000312122	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	SEC13 homolog (S. cerevisiae); Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles	0.900
B2M	SERPINA1	ENSP00000452780	ENSP00000348068	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.467
F8	MCFD2	ENSP00000353393	ENSP00000317271	coagulation factor VIII, procoagulant component; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa	multiple coagulation factor deficiency 2; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors	0.576
HLA-A	B2M	ENSP00000366005	ENSP00000452780	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.998
HLA-A	HLA-B	ENSP00000366005	ENSP00000399168	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.901
HLA-A	HLA-C	ENSP00000366005	ENSP00000365402	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-A	HLA-DRB5	ENSP00000366005	ENSP00000364114	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class II, DR beta 5	0.902
HLA-A	SAR1B	ENSP00000366005	ENSP00000385432	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	SAR1 homolog B (S. cerevisiae); Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex	0.902
HLA-A	SEC13	ENSP00000366005	ENSP00000312122	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	SEC13 homolog (S. cerevisiae); Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles	0.900
HLA-B	B2M	ENSP00000399168	ENSP00000452780	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)	0.999

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