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APC | adenomatous polyposis coli; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of M [...] (2843 aa) | |||
GRXCR1 | glutaredoxin, cysteine rich 1; May play a role in actin filament architecture in developing stereocilia of sensory cells (By similarity) (290 aa) | |||
MBD5 | methyl-CpG binding domain protein 5; Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro) (1494 aa) | |||
KIAA1549 | KIAA1549 (1950 aa) |