node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP8 | UBC | ENSP00000374423 | ENSP00000344818 | Rho GTPase activating protein 8 | ubiquitin C | 0.562 |
ATP10D | UBC | ENSP00000273859 | ENSP00000344818 | ATPase, class V, type 10D | ubiquitin C | 0.575 |
ATP11A | UBC | ENSP00000283558 | ENSP00000344818 | ATPase, class VI, type 11A | ubiquitin C | 0.890 |
ATP11B | UBC | ENSP00000321195 | ENSP00000344818 | ATPase, class VI, type 11B | ubiquitin C | 0.624 |
ATP11C | UBC | ENSP00000332756 | ENSP00000344818 | ATPase, class VI, type 11C | ubiquitin C | 0.624 |
ATP8B2 | UBC | ENSP00000357475 | ENSP00000344818 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | ubiquitin C | 0.488 |
GGPS1 | UBC | ENSP00000282841 | ENSP00000344818 | geranylgeranyl diphosphate synthase 1; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins | ubiquitin C | 0.809 |
KCTD7 | RABGEF1 | ENSP00000398177 | ENSP00000284957 | potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) | RAB guanine nucleotide exchange factor (GEF) 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) | 0.916 |
KCTD7 | UBC | ENSP00000398177 | ENSP00000344818 | potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) | ubiquitin C | 0.832 |
MOSPD2 | UBC | ENSP00000369860 | ENSP00000344818 | motile sperm domain containing 2 | ubiquitin C | 0.835 |
NUDC | UBC | ENSP00000319664 | ENSP00000344818 | nuclear distribution C homolog (A. nidulans); Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation | ubiquitin C | 0.849 |
PPP1CA | PPP4C | ENSP00000326031 | ENSP00000279387 | protein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] | protein phosphatase 4, catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-1 [...] | 0.905 |
PPP1CA | UBC | ENSP00000326031 | ENSP00000344818 | protein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] | ubiquitin C | 0.986 |
PPP4C | PPP1CA | ENSP00000279387 | ENSP00000326031 | protein phosphatase 4, catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-1 [...] | protein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] | 0.905 |
PPP4C | UBC | ENSP00000279387 | ENSP00000344818 | protein phosphatase 4, catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-1 [...] | ubiquitin C | 0.761 |
RABGEF1 | KCTD7 | ENSP00000284957 | ENSP00000398177 | RAB guanine nucleotide exchange factor (GEF) 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) | potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) | 0.916 |
RABGEF1 | UBC | ENSP00000284957 | ENSP00000344818 | RAB guanine nucleotide exchange factor (GEF) 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) | ubiquitin C | 0.999 |
UBC | ARHGAP8 | ENSP00000344818 | ENSP00000374423 | ubiquitin C | Rho GTPase activating protein 8 | 0.562 |
UBC | ATP10D | ENSP00000344818 | ENSP00000273859 | ubiquitin C | ATPase, class V, type 10D | 0.575 |
UBC | ATP11A | ENSP00000344818 | ENSP00000283558 | ubiquitin C | ATPase, class VI, type 11A | 0.890 |