Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
ENSG00000258728 ENSG00000258728 GALT GALT SLC37A2 SLC37A2 UAP1L1 UAP1L1 DIS3L2 DIS3L2 SLC37A1 SLC37A1 PGM3 PGM3 TREH TREH UBE2V1 UBE2V1 UBE2V2 UBE2V2 GNE GNE ENO1 ENO1 MPHOSPH10 MPHOSPH10 UTP3 UTP3 DIS3L DIS3L DIS3 DIS3 ENO3 ENO3 EPRS EPRS SLC37A3 SLC37A3 QARS QARS HELZ2 HELZ2 ENO4 ENO4 RIPK4 RIPK4 ENO2 ENO2 CDK1 CDK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ENO2enolase 2 (gamma, neuronal); Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity) (434 aa)
ENO1enolase 1, (alpha) (434 aa)
MPHOSPH10M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (681 aa)
UTP3UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae); Essential for gene silencing- has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity) (479 aa)
TREHtrehalase (brush-border membrane glycoprotein); Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose (582 aa)
QARSglutaminyl-tRNA synthetase (775 aa)
SLC37A2solute carrier family 37 (glycerol-3-phosphate transporter), member 2 (505 aa)
DIS3L2DIS3 mitotic control homolog (S. cerevisiae)-like 2; Ribonuclease that plays a critical role in RNA metabolism. It is essential for correct mitosis, and negatively regulates cell proliferation (885 aa)
SLC37A3solute carrier family 37 (glycerol-3-phosphate transporter), member 3 (494 aa)
DIS3LDIS3 mitotic control homolog (S. cerevisiae)-like; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3’ untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA (1054 aa)
ENO3enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration (434 aa)
RIPK4receptor-interacting serine-threonine kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation (784 aa)
UBE2V1ubiquitin-conjugating enzyme E2 variant 1 (170 aa)
SLC37A1solute carrier family 37 (glycerol-3-phosphate transporter), member 1 (533 aa)
ENO4enolase family member 4 (628 aa)
EPRSglutamyl-prolyl-tRNA synthetase (1512 aa)
DIS3DIS3 mitotic control homolog (S. cerevisiae) (958 aa)
GALTgalactose-1-phosphate uridylyltransferase (379 aa)
CDK1cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] (297 aa)
GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (753 aa)
UAP1L1UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 (507 aa)
HELZ2helicase with zinc finger 2, transcriptional coactivator; Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA (2649 aa)
PGM3phosphoglucomutase 3 (570 aa)
UBE2V2ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through ’Lys-63’. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (145 aa)
ENSG00000258728Uncharacterized protein (280 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (28%)