| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC5L | UBC | ENSP00000360532 | ENSP00000344818 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | ubiquitin C | 0.740 |
| GRB2 | PSTPIP2 | ENSP00000339007 | ENSP00000387261 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | proline-serine-threonine phosphatase interacting protein 2; Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity) | 0.667 |
| GRB2 | PTPN12 | ENSP00000339007 | ENSP00000248594 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | protein tyrosine phosphatase, non-receptor type 12; Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2 | 0.904 |
| GRB2 | PTPN18 | ENSP00000339007 | ENSP00000175756 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | protein tyrosine phosphatase, non-receptor type 18 (brain-derived); Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues | 0.639 |
| GRB2 | PTPN22 | ENSP00000339007 | ENSP00000352833 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.711 |
| GRB2 | SHC1 | ENSP00000339007 | ENSP00000401303 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | SHC (Src homology 2 domain containing) transforming protein 1 | 0.999 |
| GRB2 | UBC | ENSP00000339007 | ENSP00000344818 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | ubiquitin C | 0.949 |
| PSTPIP2 | GRB2 | ENSP00000387261 | ENSP00000339007 | proline-serine-threonine phosphatase interacting protein 2; Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity) | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.667 |
| PSTPIP2 | PTPN12 | ENSP00000387261 | ENSP00000248594 | proline-serine-threonine phosphatase interacting protein 2; Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity) | protein tyrosine phosphatase, non-receptor type 12; Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2 | 0.699 |
| PSTPIP2 | PTPN18 | ENSP00000387261 | ENSP00000175756 | proline-serine-threonine phosphatase interacting protein 2; Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity) | protein tyrosine phosphatase, non-receptor type 18 (brain-derived); Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues | 0.663 |
| PTPN12 | GRB2 | ENSP00000248594 | ENSP00000339007 | protein tyrosine phosphatase, non-receptor type 12; Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.904 |
| PTPN12 | PSTPIP2 | ENSP00000248594 | ENSP00000387261 | protein tyrosine phosphatase, non-receptor type 12; Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2 | proline-serine-threonine phosphatase interacting protein 2; Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity) | 0.699 |
| PTPN12 | SHC1 | ENSP00000248594 | ENSP00000401303 | protein tyrosine phosphatase, non-receptor type 12; Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.994 |
| PTPN18 | GRB2 | ENSP00000175756 | ENSP00000339007 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived); Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.639 |
| PTPN18 | PSTPIP2 | ENSP00000175756 | ENSP00000387261 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived); Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues | proline-serine-threonine phosphatase interacting protein 2; Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity) | 0.663 |
| PTPN22 | GRB2 | ENSP00000352833 | ENSP00000339007 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.711 |
| SHC1 | GRB2 | ENSP00000401303 | ENSP00000339007 | SHC (Src homology 2 domain containing) transforming protein 1 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.999 |
| SHC1 | PTPN12 | ENSP00000401303 | ENSP00000248594 | SHC (Src homology 2 domain containing) transforming protein 1 | protein tyrosine phosphatase, non-receptor type 12; Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2 | 0.994 |
| SHC1 | UBC | ENSP00000401303 | ENSP00000344818 | SHC (Src homology 2 domain containing) transforming protein 1 | ubiquitin C | 0.850 |
| UBC | CDC5L | ENSP00000344818 | ENSP00000360532 | ubiquitin C | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.740 |
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