Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
IMPACT IMPACT EEF1A2 EEF1A2 GCN1L1 GCN1L1 DRG1 DRG1 ZC3H15 ZC3H15 BTF3 BTF3 EEF1A1 EEF1A1 DRG2 DRG2 RWDD4 RWDD4 UBC UBC CUL5 CUL5 ESF1 ESF1 KCTD17 KCTD17 NOP2 NOP2 ELAVL1 ELAVL1 CUL4B CUL4B NSUN3 NSUN3 NSUN6 NSUN6 NSUN2 NSUN2 NSUN5 NSUN5 NSUN7 NSUN7 NSUN4 NSUN4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ESF1ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae); May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) (851 aa)
EEF1A2eukaryotic translation elongation factor 1 alpha 2; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (463 aa)
DRG2developmentally regulated GTP binding protein 2; May play a role in cell proliferation, differentiation and death (364 aa)
NSUN2NOP2/Sun RNA methyltransferase family, member 2; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity (767 aa)
IMPACTImpact homolog (mouse); Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis (By similarity) (320 aa)
GCN1L1GCN1 general control of amino-acid synthesis 1-like 1 (yeast) (2671 aa)
NSUN5NOP2/Sun domain family, member 5 (470 aa)
NSUN3NOP2/Sun domain family, member 3; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) (340 aa)
DRG1developmentally regulated GTP binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest (367 aa)
EEF1A1eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (462 aa)
ZC3H15zinc finger CCCH-type containing 15; Protects DRG1 from proteolytic degradation (By similarity) (426 aa)
UBCubiquitin C (685 aa)
NSUN6NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) (469 aa)
BTF3basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription (206 aa)
NSUN7NOP2/Sun domain family, member 7; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) (718 aa)
CUL5cullin 5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by [...] (780 aa)
NOP2NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase (808 aa)
CUL4Bcullin 4B (913 aa)
KCTD17potassium channel tetramerisation domain containing 17 (297 aa)
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa)
RWDD4RWD domain containing 4 (188 aa)
NSUN4NOP2/Sun domain family, member 4; Involved in mitochondrial ribosome large subunit biogenesis (384 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (30%)