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BYSL | bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos (437 aa) | |||
GNG11 | guanine nucleotide binding protein (G protein), gamma 11; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) (73 aa) | |||
ERAL1 | Era G-protein-like 1 (E. coli); Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3’ terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (437 aa) | |||
CHIC2 | cysteine-rich hydrophobic domain 2 (165 aa) | |||
PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (534 aa) | |||
CCDC116 | coiled-coil domain containing 116 (613 aa) | |||
DHX57 | DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57; Probable ATP-binding RNA helicase (1386 aa) | |||
ANKRD11 | ankyrin repeat domain 11; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (2663 aa) | |||
SPERT | spermatid associated (448 aa) | |||
ZNF417 | zinc finger protein 417; May be involved in transcriptional regulation (575 aa) | |||
MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 (1093 aa) | |||
MRFAP1L1 | Morf4 family associated protein 1-like 1 (127 aa) | |||
TRIM41 | tripartite motif containing 41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C (630 aa) | |||
ING5 | inhibitor of growth family, member 5; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (240 aa) | |||
CXorf27 | chromosome X open reading frame 27 (117 aa) | |||
UBC | ubiquitin C (685 aa) | |||
ZNF587 | zinc finger protein 587; May be involved in transcriptional regulation (575 aa) | |||
TSGA10 | testis specific, 10; May play a role in the sperm tail fibrous sheath, a major sperm tail structure (By similarity) (698 aa) | |||
POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae); Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP (163 aa) | |||
CEP57L1 | centrosomal protein 57kDa-like 1; Centrosomal protein which may be required for microtubule attachment to centrosomes (By similarity) (460 aa) | |||
RNF8 | ring finger protein 8, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles- by mediating the ’Lys-63’- linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing ’Lys-48’-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the ’Lys-63’-linked ubiquitination of histones H2A and H2AX, thereby promoting th [...] (485 aa) | |||
LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5’-AGCCCCCGGCG-3’) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (808 aa) | |||
CDC23 | cell division cycle 23 homolog (S. cerevisiae); Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains (597 aa) | |||
MAPK9 | mitogen-activated protein kinase 9 (424 aa) | |||
CEP44 | centrosomal protein 44kDa (399 aa) | |||
DIP2A | DIP2 disco-interacting protein 2 homolog A (Drosophila); May provide positional cues for axon pathfinding and patterning in the central nervous system (1571 aa) |