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STRINGSTRING
ENO1 ENO1 ARFRP1 ARFRP1 AP3D1 AP3D1 BET3L BET3L STX16 STX16 TRAPPC10 TRAPPC10 ENSG00000254995 ENSG00000254995 TRAPPC6A TRAPPC6A TRAPPC8 TRAPPC8 TRAPPC6B TRAPPC6B TRAPPC11 TRAPPC11 COG6 COG6 TRAPPC4 TRAPPC4 TRAPPC2 TRAPPC2 TRAPPC9 TRAPPC9 TRAPPC5 TRAPPC5 ARL13B ARL13B TRAPPC3 TRAPPC3 TRAPPC1 TRAPPC1 RAB3IP RAB3IP TRAPPC12 TRAPPC12 CLINT1 CLINT1 ELAVL1 ELAVL1 JOSD2 JOSD2 ZBED1 ZBED1 CLIC2 CLIC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TRAPPC6Atrafficking protein particle complex 6A; May play a role in vesicular transport during the biogenesis of melanosomes (By similarity) (173 aa)
ENO1enolase 1, (alpha) (434 aa)
TRAPPC8trafficking protein particle complex 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (1435 aa)
TRAPPC10trafficking protein particle complex 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi (1259 aa)
TRAPPC1trafficking protein particle complex 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi (145 aa)
TRAPPC5trafficking protein particle complex 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi (188 aa)
TRAPPC12trafficking protein particle complex 12; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (735 aa)
ARFRP1ADP-ribosylation factor related protein 1; Possibly involved in plasma membrane-related signaling events (201 aa)
TRAPPC6Btrafficking protein particle complex 6B; May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) (158 aa)
TRAPPC11trafficking protein particle complex 11 (1133 aa)
AP3D1adaptor-related protein complex 3, delta 1 subunit; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (1153 aa)
BET3LBET3 like (S. cerevisiae); May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity) (181 aa)
CLIC2chloride intracellular channel 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx (247 aa)
STX16syntaxin 16 (325 aa)
TRAPPC3trafficking protein particle complex 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi (180 aa)
ZBED1zinc finger, BED-type containing 1; Binds to 5’-TGTCG[CT]GA[CT]A-3’ DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity (694 aa)
TRAPPC9trafficking protein particle complex 9 (1246 aa)
JOSD2Josephin domain containing 2; Cleaves ’Lys-63’-linked poly-ubiquitin chains, and with lesser efficiency ’Lys-48’-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme (188 aa)
ARL13BADP-ribosylation factor-like 13B (428 aa)
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa)
TRAPPC2trafficking protein particle complex 2; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi (174 aa)
COG6component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) (657 aa)
CLINT1clathrin interactor 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (643 aa)
TRAPPC4trafficking protein particle complex 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi (219 aa)
RAB3IPRAB3A interacting protein (rabin3) (476 aa)
ENSG00000254995STX16-NPEPL1 readthrough (non-protein coding) (382 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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