Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | HSPB11 | heat shock protein family B (small), member 11 (144 aa) | ||
 | RAB3D | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) (219 aa) | ||
 | RAB3A | RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (220 aa) | ||
 | IFT43 | intraflagellar transport 43 homolog (Chlamydomonas); Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (213 aa) | ||
 | IFT81 | intraflagellar transport 81 homolog (Chlamydomonas); Isoform CDV-1 may be involved in cardiac hypertrophy caused by carnitine deficiency (By similarity) (676 aa) | ||
 | TTC21B | tetratricopeptide repeat domain 21B (1316 aa) | ||
 | DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 (351 aa) | ||
 | PRDX5 | peroxiredoxin 5; Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling (214 aa) | ||
 | DENND2A | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport (1009 aa) | ||
 | RAB3C | RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (227 aa) | ||
 | IFT122 | intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity) (1292 aa) | ||
 | WDR35 | WD repeat domain 35; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis (1181 aa) | ||
 | ST5 | suppression of tumorigenicity 5 (1137 aa) | ||
 | DENND2D | DENN/MADD domain containing 2D; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form (471 aa) | ||
 | IFT20 | intraflagellar transport 20 homolog (Chlamydomonas); Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (148 aa) | ||
 | RABIF | RAB interacting factor; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport (123 aa) | ||
 | DENND1B | DENN/MADD domain containing 1B (426 aa) | ||
 | RAB3B | RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (219 aa) | ||
 | IFT52 | intraflagellar transport 52 homolog (Chlamydomonas) (437 aa) | ||
 | DENND1A | DENN/MADD domain containing 1A (1009 aa) | ||
 | IFT74 | intraflagellar transport 74 homolog (Chlamydomonas) (600 aa) | ||
 | DENND1C | DENN/MADD domain containing 1C; Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (801 aa) | ||
 | DENND2C | DENN/MADD domain containing 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form (871 aa) | ||
 | WDR19 | WD repeat domain 19; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in cilia function and/or assembly (By similarity) (1342 aa) | ||
 | IFT27 | intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity) (186 aa) | ||
 | IFT140 | intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance (1462 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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