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ARHGAP11A ARHGAP11A FAM13B FAM13B SRGAP3 SRGAP3 OPHN1 OPHN1 SRGAP2 SRGAP2 ARHGAP36 ARHGAP36 DEPDC1B DEPDC1B TRIP10 TRIP10 ARHGAP18 ARHGAP18 ARHGAP32 ARHGAP32 RHOBTB2 RHOBTB2 RHOD RHOD RHOC RHOC RHOH RHOH RHOG RHOG ARHGAP20 ARHGAP20 RALBP1 RALBP1 FGD4 FGD4 ARHGAP33 ARHGAP33 INPP5B INPP5B ARHGAP22 ARHGAP22 ARHGAP40 ARHGAP40 CHN1 CHN1 ARHGAP30 ARHGAP30 ARHGAP24 ARHGAP24 GMIP GMIP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RALBP1ralA binding protein 1; Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off [...] (655 aa)
FAM13Bfamily with sequence similarity 13, member B (915 aa)
GMIPGEM interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA (970 aa)
ARHGAP22Rho GTPase activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity) (698 aa)
ARHGAP20Rho GTPase activating protein 20 (1191 aa)
DEPDC1BDEP domain containing 1B (529 aa)
ARHGAP18Rho GTPase activating protein 18; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (663 aa)
ARHGAP36Rho GTPase activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (547 aa)
RHOCras homolog family member C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (193 aa)
SRGAP2SLIT-ROBO Rho GTPase activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] (985 aa)
RHODras homolog family member D; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton (By similarity) (210 aa)
ARHGAP32Rho GTPase activating protein 32; GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity) (2087 aa)
ARHGAP33Rho GTPase activating protein 33; May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity) (1126 aa)
TRIP10thyroid hormone receptor interactor 10 (545 aa)
RHOGras homolog family member G; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry (191 aa)
OPHN1oligophrenin 1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function (By similarity). Critical for the stabilization of AMPA receptors at postsynaptic sites (By similarity). Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity) (802 aa)
ARHGAP11ARho GTPase activating protein 11A (1023 aa)
ARHGAP30Rho GTPase activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42 (1101 aa)
INPP5Binositol polyphosphate-5-phosphatase, 75kDa (913 aa)
ARHGAP40Rho GTPase activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (622 aa)
RHOHras homolog family member H; Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation durin [...] (191 aa)
SRGAP3SLIT-ROBO Rho GTPase activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons (1099 aa)
ARHGAP24Rho GTPase activating protein 24; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamel [...] (748 aa)
CHN1chimerin 1; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance (459 aa)
FGD4FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) (766 aa)
RHOBTB2Rho-related BTB domain containing 2 (749 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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