node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
E2F3 | SYTL5 | ENSP00000262904 | ENSP00000395220 | E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.575 |
EZR | MSN | ENSP00000338934 | ENSP00000353408 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage | 0.936 |
EZR | NF2 | ENSP00000338934 | ENSP00000344666 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | neurofibromin 2 (merlin) | 0.821 |
EZR | RDX | ENSP00000338934 | ENSP00000342830 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | radixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane | 0.867 |
MSN | EZR | ENSP00000353408 | ENSP00000338934 | moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | 0.936 |
NF2 | EZR | ENSP00000344666 | ENSP00000338934 | neurofibromin 2 (merlin) | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | 0.821 |
RAB18 | WAC | ENSP00000349415 | ENSP00000346986 | RAB18, member RAS oncogene family; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration | WW domain containing adaptor with coiled-coil | 0.585 |
RAB27A | SYTL5 | ENSP00000337761 | ENSP00000395220 | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.937 |
RAB27B | SYTL5 | ENSP00000262094 | ENSP00000395220 | RAB27B, member RAS oncogene family; May be involved in targeting uroplakins to urothelial apical membranes (By similarity) | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.812 |
RAB3A | SYTL5 | ENSP00000222256 | ENSP00000395220 | RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.754 |
RAB6A | SYTL5 | ENSP00000311449 | ENSP00000395220 | RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.663 |
RDX | EZR | ENSP00000342830 | ENSP00000338934 | radixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | 0.867 |
SYTL5 | E2F3 | ENSP00000395220 | ENSP00000262904 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner | 0.575 |
SYTL5 | RAB27A | ENSP00000395220 | ENSP00000337761 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse | 0.937 |
SYTL5 | RAB27B | ENSP00000395220 | ENSP00000262094 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | RAB27B, member RAS oncogene family; May be involved in targeting uroplakins to urothelial apical membranes (By similarity) | 0.812 |
SYTL5 | RAB3A | ENSP00000395220 | ENSP00000222256 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal | 0.754 |
SYTL5 | RAB6A | ENSP00000395220 | ENSP00000311449 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity | 0.663 |
SYTL5 | WAC | ENSP00000395220 | ENSP00000346986 | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | WW domain containing adaptor with coiled-coil | 0.534 |
WAC | RAB18 | ENSP00000346986 | ENSP00000349415 | WW domain containing adaptor with coiled-coil | RAB18, member RAS oncogene family; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration | 0.585 |
WAC | SYTL5 | ENSP00000346986 | ENSP00000395220 | WW domain containing adaptor with coiled-coil | synaptotagmin-like 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids | 0.534 |