node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG7 | MAN2B1 | ENSP00000346437 | ENSP00000395473 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | 0.414 |
ATG7 | UBC | ENSP00000346437 | ENSP00000344818 | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | ubiquitin C | 0.635 |
DNAJB11 | MAN2B1 | ENSP00000265028 | ENSP00000395473 | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | 0.644 |
DNAJB11 | UBC | ENSP00000265028 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | ubiquitin C | 0.754 |
GOLGA2 | UBC | ENSP00000416097 | ENSP00000344818 | golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure | ubiquitin C | 0.730 |
LUC7L2 | MAN2B1 | ENSP00000347005 | ENSP00000395473 | LUC7-like 2 (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | 0.404 |
LUC7L2 | UBC | ENSP00000347005 | ENSP00000344818 | LUC7-like 2 (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain | ubiquitin C | 0.800 |
MAN2B1 | ATG7 | ENSP00000395473 | ENSP00000346437 | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | 0.414 |
MAN2B1 | DNAJB11 | ENSP00000395473 | ENSP00000265028 | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | 0.644 |
MAN2B1 | LUC7L2 | ENSP00000395473 | ENSP00000347005 | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | LUC7-like 2 (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain | 0.404 |
MAN2B1 | NAGA | ENSP00000395473 | ENSP00000379680 | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | N-acetylgalactosaminidase, alpha-; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids | 0.405 |
MAN2B1 | NKX3-1 | ENSP00000395473 | ENSP00000370253 | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | NK3 homeobox 1; Transcription factor, which binds preferentially the consensus sequence 5’-TAAGT[AG]-3’ and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells | 0.547 |
MAN2B1 | SEC24A | ENSP00000395473 | ENSP00000381823 | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | SEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex | 0.405 |
NAGA | MAN2B1 | ENSP00000379680 | ENSP00000395473 | N-acetylgalactosaminidase, alpha-; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | 0.405 |
NKX3-1 | MAN2B1 | ENSP00000370253 | ENSP00000395473 | NK3 homeobox 1; Transcription factor, which binds preferentially the consensus sequence 5’-TAAGT[AG]-3’ and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | 0.547 |
SEC24A | MAN2B1 | ENSP00000381823 | ENSP00000395473 | SEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex | mannosidase, alpha, class 2B, member 1; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages | 0.405 |
SEC24A | UBC | ENSP00000381823 | ENSP00000344818 | SEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex | ubiquitin C | 0.807 |
UBC | ATG7 | ENSP00000344818 | ENSP00000346437 | ubiquitin C | autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) | 0.635 |
UBC | DNAJB11 | ENSP00000344818 | ENSP00000265028 | ubiquitin C | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | 0.754 |
UBC | GOLGA2 | ENSP00000344818 | ENSP00000416097 | ubiquitin C | golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure | 0.730 |