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ALDH3A1 ALDH3A1 FLOT1 FLOT1 PLP2 PLP2 ALDH1A1 ALDH1A1 LGALS3 LGALS3 ALDH16A1 ALDH16A1 ALDH1A2 ALDH1A2 CD55 CD55 LGALS9 LGALS9 HSD17B10 HSD17B10 LGALS9C LGALS9C ALDH1A3 ALDH1A3 ALDH3A2 ALDH3A2 SLC12A4 SLC12A4 TMEM43 TMEM43 ALDH3B2 ALDH3B2 ALDH1L2 ALDH1L2 ENSG00000257767 ENSG00000257767 ILF3 ILF3 ALDH4A1 ALDH4A1 ALDH2 ALDH2 ALDH8A1 ALDH8A1 ALDH9A1 ALDH9A1 ENSG00000255275 ENSG00000255275 ENSG00000269469 ENSG00000269469 ALDH7A1 ALDH7A1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
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protein homology
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HSD17B10hydroxysteroid (17-beta) dehydrogenase 10; Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (261 aa)
ALDH3A1aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes (453 aa)
ALDH1A2aldehyde dehydrogenase 1 family, member A2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity) (518 aa)
LGALS3lectin, galactoside-binding, soluble, 3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus- acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (250 aa)
ALDH3B2aldehyde dehydrogenase 3 family, member B2 (385 aa)
ALDH1L2aldehyde dehydrogenase 1 family, member L2 (923 aa)
ALDH2aldehyde dehydrogenase 2 family (mitochondrial) (517 aa)
ALDH8A1aldehyde dehydrogenase 8 family, member A1; Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro) (487 aa)
ALDH4A1aldehyde dehydrogenase 4 family, member A1 (563 aa)
ALDH16A1aldehyde dehydrogenase 16 family, member A1 (802 aa)
ALDH1A1aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) (501 aa)
TMEM43transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) (400 aa)
CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (440 aa)
LGALS9Clectin, galactoside-binding, soluble, 9C; Binds galactosides (By similarity) (356 aa)
ALDH1A3aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) (512 aa)
ALDH3A2aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (508 aa)
ALDH9A1aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction (518 aa)
PLP2proteolipid protein 2 (colonic epithelium-enriched); May play a role in cell differentiation in the intestinal epithelium (152 aa)
FLOT1flotillin 1 (427 aa)
LGALS9lectin, galactoside-binding, soluble, 9; Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant (355 aa)
ALDH7A1aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (539 aa)
SLC12A4solute carrier family 12 (potassium/chloride transporters), member 4 (1087 aa)
ILF3interleukin enhancer binding factor 3, 90kDa (898 aa)
ENSG00000257767Uncharacterized protein (245 aa)
ENSG00000255275annotation not available (296 aa)
ENSG00000269469Uncharacterized protein (72 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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