Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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 | SLC22A11 | solute carrier family 22 (organic anion/urate transporter), member 11; Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds (550 aa) | ||
 | TMEM43 | transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) (400 aa) | ||
 | SLC22A25 | solute carrier family 22, member 25 (547 aa) | ||
 | SPNS1 | spinster homolog 1 (Drosophila) (528 aa) | ||
 | SLC16A11 | solute carrier family 16, member 11 (monocarboxylic acid transporter 11); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity) (471 aa) | ||
 | CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (440 aa) | ||
 | SLC16A8 | solute carrier family 16, member 8 (monocarboxylic acid transporter 3); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) (504 aa) | ||
 | SLC2A2 | solute carrier family 2 (facilitated glucose transporter), member 2; Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (524 aa) | ||
 | SLC22A10 | solute carrier family 22, member 10 (541 aa) | ||
 | SLC16A5 | solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) (505 aa) | ||
 | SV2B | synaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells (By similarity) (683 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | SLC22A1 | solute carrier family 22 (organic cation transporter), member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), coca [...] (554 aa) | ||
 | MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity) (978 aa) | ||
 | SLC16A10 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) (515 aa) | ||
 | ALDH18A1 | aldehyde dehydrogenase 18 family, member A1 (795 aa) | ||
 | SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5; Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter (501 aa) | ||
 | SLC22A6 | solute carrier family 22 (organic anion transporter), member 6 (563 aa) | ||
 | SLC16A9 | solute carrier family 16, member 9 (monocarboxylic acid transporter 9); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity) (509 aa) | ||
 | SLC17A3 | solute carrier family 17 (sodium phosphate), member 3; Isoform 2- voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport (498 aa) | ||
 | SLC2A11 | solute carrier family 2 (facilitated glucose transporter), member 11; Facilitative glucose transporter (503 aa) | ||
 | SLC12A4 | solute carrier family 12 (potassium/chloride transporters), member 4 (1087 aa) | ||
 | ENSG00000251357 | Uncharacterized protein (176 aa) | ||
 | MFSD1 | major facilitator superfamily domain containing 1 (514 aa) | ||
 | ILF3 | interleukin enhancer binding factor 3, 90kDa (898 aa) | ||
 | MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (935 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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