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SLC22A6 SLC22A6 SLC22A12 SLC22A12 SLC17A3 SLC17A3 SLC22A7 SLC22A7 SLC16A12 SLC16A12 SLC16A9 SLC16A9 SLC22A1 SLC22A1 SLC22A2 SLC22A2 SLC2A7 SLC2A7 SLC22A24 SLC22A24 SLC33A1 SLC33A1 SLC2A1 SLC2A1 ENSG00000251357 ENSG00000251357 SLC2A14 SLC2A14 UBC UBC CD55 CD55 SLC12A4 SLC12A4 MTHFD1 MTHFD1 SLC2A5 SLC2A5 ILF3 ILF3 ALDH18A1 ALDH18A1 SLC2A11 SLC2A11 TMEM43 TMEM43 MTHFD1L MTHFD1L MFSD1 MFSD1 SLC16A10 SLC16A10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TMEM43transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity) (400 aa)
CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group); This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (440 aa)
UBCubiquitin C (685 aa)
SLC33A1solute carrier family 33 (acetyl-CoA transporter), member 1; Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides (549 aa)
SLC22A2solute carrier family 22 (organic cation transporter), member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited b [...] (555 aa)
SLC22A1solute carrier family 22 (organic cation transporter), member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), coca [...] (554 aa)
MTHFD1Lmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity) (978 aa)
SLC16A10solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) (515 aa)
ALDH18A1aldehyde dehydrogenase 18 family, member A1 (795 aa)
SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity) (516 aa)
SLC22A7solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate (548 aa)
SLC2A5solute carrier family 2 (facilitated glucose/fructose transporter), member 5; Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter (501 aa)
SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions (553 aa)
SLC22A6solute carrier family 22 (organic anion transporter), member 6 (563 aa)
SLC16A9solute carrier family 16, member 9 (monocarboxylic acid transporter 9); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity) (509 aa)
SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14; Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis (520 aa)
SLC17A3solute carrier family 17 (sodium phosphate), member 3; Isoform 2- voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport (498 aa)
SLC2A11solute carrier family 2 (facilitated glucose transporter), member 11; Facilitative glucose transporter (503 aa)
SLC2A7solute carrier family 2 (facilitated glucose transporter), member 7; High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose (512 aa)
SLC12A4solute carrier family 12 (potassium/chloride transporters), member 4 (1087 aa)
SLC22A24solute carrier family 22, member 24 (551 aa)
ENSG00000251357Uncharacterized protein (176 aa)
MFSD1major facilitator superfamily domain containing 1 (514 aa)
ILF3interleukin enhancer binding factor 3, 90kDa (898 aa)
SLC2A1solute carrier family 2 (facilitated glucose transporter), member 1; Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (492 aa)
MTHFD1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (935 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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