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FCN1 FCN1 COLEC11 COLEC11 MBL2 MBL2 FCN3 FCN3 COLEC10 COLEC10 MASP1 MASP1 MASP2 MASP2 CHCHD1 CHCHD1 C1S C1S C1QB C1QB FCN2 FCN2 C1QA C1QA C4B C4B C1QC C1QC C4A C4A C1R C1R CD46 CD46 C3 C3 MRPS18B MRPS18B MRPS26 MRPS26 CFI CFI MRPS35 MRPS35 MRPS7 MRPS7 C5 C5 MRPS11 MRPS11 MRPS24 MRPS24
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
MRPS35mitochondrial ribosomal protein S35 (323 aa)
C5complement component 5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled (1676 aa)
MRPS7mitochondrial ribosomal protein S7 (242 aa)
C3complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (1663 aa)
MRPS18Bmitochondrial ribosomal protein S18B (258 aa)
FCN3ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota (299 aa)
C1Rcomplement component 1, r subcomponent (668 aa)
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region (313 aa)
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (728 aa)
CD46CD46 molecule, complement regulatory protein (399 aa)
C1QBcomplement component 1, q subcomponent, B chain; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes (253 aa)
MRPS11mitochondrial ribosomal protein S11 (194 aa)
MRPS24mitochondrial ribosomal protein S24 (167 aa)
C1Scomplement component 1, s subcomponent (688 aa)
COLEC10collectin sub-family member 10 (C-type lectin); Lectin that binds to various sugars- galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (277 aa)
COLEC11collectin sub-family member 11 (271 aa)
FCN1ficolin (collagen/fibrinogen domain containing) 1; Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2- 6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (326 aa)
CHCHD1coiled-coil-helix-coiled-coil-helix domain containing 1 (118 aa)
MBL2mannose-binding lectin (protein C) 2, soluble; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA (248 aa)
C1QCcomplement component 1, q subcomponent, C chain; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes (245 aa)
C1QAcomplement component 1, q subcomponent, A chain; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes (245 aa)
MRPS26mitochondrial ribosomal protein S26 (205 aa)
CFIcomplement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively (583 aa)
MASP2mannan-binding lectin serine peptidase 2 (686 aa)
C4Acomplement component 4A (Rodgers blood group) (1744 aa)
C4Bcomplement component 4B (Chido blood group) (1744 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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