Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | PRDM4 | PR domain containing 4; May function as a transcription factor involved in cell differentiation (By similarity) (801 aa) | ||
 | TRIM28 | tripartite motif containing 28; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitm [...] (835 aa) | ||
 | MECOM | MDS1 and EVI1 complex locus (1116 aa) | ||
 | PRDM15 | PR domain containing 15; May be involved in transcriptional regulation (1507 aa) | ||
 | PRDM14 | PR domain containing 14; Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels- the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5’-GGT [...] (571 aa) | ||
 | ZNF773 | zinc finger protein 773; May be involved in transcriptional regulation (442 aa) | ||
 | ZNF582 | zinc finger protein 582; May be involved in transcriptional regulation (517 aa) | ||
 | ZNF584 | zinc finger protein 584; May be involved in transcriptional regulation (421 aa) | ||
 | ZNF408 | zinc finger protein 408; May be involved in transcriptional regulation (720 aa) | ||
 | ZNF80 | zinc finger protein 80; May be involved in transcriptional regulation (273 aa) | ||
 | EBF1 | early B-cell factor 1; Transcriptional activator which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) (591 aa) | ||
 | ZNF479 | zinc finger protein 479; May be involved in transcriptional regulation (524 aa) | ||
 | PRDM8 | PR domain containing 8; May be involved in transcriptional regulation (689 aa) | ||
 | ZNF81 | zinc finger protein 81; May be involved in transcriptional regulation (661 aa) | ||
 | ZNF589 | zinc finger protein 589; May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor (364 aa) | ||
 | ZNF44 | zinc finger protein 44; May be involved in transcriptional regulation (663 aa) | ||
 | ZNF567 | zinc finger protein 567; May be involved in transcriptional regulation (616 aa) | ||
 | EBF3 | early B-cell factor 3; Transcriptional activator which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) (551 aa) | ||
 | EBF4 | early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) (598 aa) | ||
 | ZBTB9 | zinc finger and BTB domain containing 9 (473 aa) | ||
 | ZNF208 | zinc finger protein 208 (1280 aa) | ||
 | ZNF419 | zinc finger protein 419; May be involved in transcriptional regulation (511 aa) | ||
 | PRDM7 | PR domain containing 7; Probable histone methyltransferase (By similarity) (492 aa) | ||
 | ZNF347 | zinc finger protein 347; May be involved in transcriptional regulation (840 aa) | ||
 | EBF2 | early B-cell factor 2; Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt- responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity) (575 aa) | ||
 | ZNF286 | Zinc finger protein 286A; cDNA FLJ55788, highly similar to Zinc finger protein 286 ; May be involved in transcriptional regulation (521 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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