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FAM48A FAM48A TAF7 TAF7 SAP130 SAP130 TAF4 TAF4 SUPT7L SUPT7L TADA2B TADA2B TAF2 TAF2 TADA3 TADA3 TAF10 TAF10 TAF6L TAF6L TADA1 TADA1 TAF5 TAF5 TRRAP TRRAP TADA2A TADA2A TAF6 TAF6 USP22 USP22 SUPT3H SUPT3H ATXN7L2 ATXN7L2 ATXN7L3 ATXN7L3 TAF12 TAF12 TAF5L TAF5L ENSG00000258130 ENSG00000258130 ATXN7L1 ATXN7L1 ENSG00000258150 ENSG00000258150 ATXN7 ATXN7
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
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co-expression
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FAM48Afamily with sequence similarity 48, member A; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down- regulation of E-cadherin during gastrulation by regulating E- cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation- induced ATG9A trafficking during autophagy (779 aa)
TADA2Atranscriptional adaptor 2A; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (443 aa)
TAF4TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa; Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (1085 aa)
TAF5LTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (589 aa)
USP22ubiquitin specific peptidase 22; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (525 aa)
TAF12TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (161 aa)
TAF6LTAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (622 aa)
TAF10TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (218 aa)
TADA3transcriptional adaptor 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (432 aa)
TADA2Btranscriptional adaptor 2B; Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2 (420 aa)
TAF7TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa; Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively) (349 aa)
SUPT7Lsuppressor of Ty 7 (S. cerevisiae)-like (414 aa)
TRRAPtransformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription acti [...] (3830 aa)
SAP130Sin3A-associated protein, 130kDa; Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (1083 aa)
TADA1transcriptional adaptor 1; Probably involved in transcriptional regulation (335 aa)
TAF5TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, a [...] (800 aa)
ATXN7L2ataxin 7-like 2 (722 aa)
SUPT3Hsuppressor of Ty 3 homolog (S. cerevisiae); Probable transcriptional activator (328 aa)
TAF2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter (1199 aa)
ATXN7ataxin 7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization (945 aa)
ATXN7L3ataxin 7-like 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into [...] (354 aa)
TAF6TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (714 aa)
ATXN7L1ataxin 7-like 1 (861 aa)
ENSG00000258130Uncharacterized protein (439 aa)
ENSG00000258150Uncharacterized protein (439 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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