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PFN2 PFN2 DLK2 DLK2 GRID2 GRID2 SCUBE3 SCUBE3 PFN4 PFN4 TDGF1 TDGF1 BAIAP2L1 BAIAP2L1 GRID2IP GRID2IP F12 F12 HABP2 HABP2 CFC1B CFC1B PFN1 PFN1 COL14A1 COL14A1 SNED1 SNED1 COL22A1 COL22A1 VWCE VWCE IRF2BP2 IRF2BP2 DLL4 DLL4 FRAS1 FRAS1 NDUFB10 NDUFB10 CRIM1 CRIM1 SORBS2 SORBS2 EGFL7 EGFL7 HGFAC HGFAC C9orf172 C9orf172 VWA1 VWA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
BAIAP2L1BAI1-associated protein 2-like 1; May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (511 aa)
PFN1profilin 1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (140 aa)
PFN2profilin 2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (140 aa)
DLL4delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) (685 aa)
F12coagulation factor XII (Hageman factor); Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (615 aa)
FRAS1Fraser syndrome 1 (4012 aa)
NDUFB10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (172 aa)
SCUBE3signal peptide, CUB domain, EGF-like 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression (993 aa)
HABP2hyaluronan binding protein 2; Cleaves the alpha-chain at multiple sites and the beta- chain between ’Lys-53’ and ’Lys-54’ but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII (560 aa)
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like); May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (1036 aa)
CFC1Bcripto, FRL-1, cryptic family 1B (223 aa)
GRID2glutamate receptor, ionotropic, delta 2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists (1007 aa)
SORBS2sorbin and SH3 domain containing 2 (1100 aa)
TDGF1teratocarcinoma-derived growth factor 1; Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Activates the Nodal-dependent signaling pathway (188 aa)
COL14A1collagen, type XIV, alpha 1 (1796 aa)
COL22A1collagen, type XXII, alpha 1; Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts (1626 aa)
EGFL7EGF-like-domain, multiple 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro (By similarity) (273 aa)
SNED1sushi, nidogen and EGF-like domains 1 (1413 aa)
PFN4profilin family, member 4; Binds to actin and affects the structure of the cytoskeleton (By similarity) (129 aa)
VWCEvon Willebrand factor C and EGF domains; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma (955 aa)
DLK2delta-like 2 homolog (Drosophila); Regulates adipogenesis (By similarity) (383 aa)
IRF2BP2interferon regulatory factor 2 binding protein 2; Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle (587 aa)
HGFACHGF activator; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form (655 aa)
GRID2IPglutamate receptor, ionotropic, delta 2 (Grid2) interacting protein; Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules (By similarity) (1211 aa)
C9orf172chromosome 9 open reading frame 172 (976 aa)
VWA1von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity) (445 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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