15 items (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	GTPBP1	GTP binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity) (669 aa)
	USP15	ubiquitin specific peptidase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear- according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed-21947082). According to another reports, regulates the TGF-beta receptor s [...] (952 aa)
	GALC	galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (685 aa)
	METTL21C	methyltransferase like 21C; Protein-lysine methyltransferase (264 aa)
	WBSCR27	Williams Beuren syndrome chromosome region 27 (245 aa)
	EEF2	eukaryotic translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (858 aa)
	PRTFDC1	phosphoribosyl transferase domain containing 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage (225 aa)
	BCAT2	branched chain amino-acid transaminase 2, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (392 aa)
	PARL	presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (379 aa)
	FAM86C1	family with sequence similarity 86, member C1 (165 aa)
	ECI2	enoyl-CoA delta isomerase 2 (394 aa)
	METTL21A	methyltransferase like 21A; Protein-lysine methyltransferase (218 aa)
	FAM86A	family with sequence similarity 86, member A (330 aa)
	WBSCR22	Williams Beuren syndrome chromosome region 22 (298 aa)
	ENSG00000267168	Uncharacterized protein (100 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEF2	FAM86A	ENSP00000307940	ENSP00000398502	eukaryotic translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	family with sequence similarity 86, member A	0.784
ENSG00000267168	FAM86A	ENSP00000466829	ENSP00000398502	Uncharacterized protein	family with sequence similarity 86, member A	0.551
ENSG00000267168	FAM86C1	ENSP00000466829	ENSP00000352182	Uncharacterized protein	family with sequence similarity 86, member C1	0.551
FAM86A	EEF2	ENSP00000398502	ENSP00000307940	family with sequence similarity 86, member A	eukaryotic translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	0.784
FAM86A	ENSG00000267168	ENSP00000398502	ENSP00000466829	family with sequence similarity 86, member A	Uncharacterized protein	0.551
FAM86A	METTL21A	ENSP00000398502	ENSP00000385481	family with sequence similarity 86, member A	methyltransferase like 21A; Protein-lysine methyltransferase	0.551
FAM86A	METTL21C	ENSP00000398502	ENSP00000267273	family with sequence similarity 86, member A	methyltransferase like 21C; Protein-lysine methyltransferase	0.551
FAM86A	PRTFDC1	ENSP00000398502	ENSP00000318602	family with sequence similarity 86, member A	phosphoribosyl transferase domain containing 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage	0.796
FAM86C1	ENSG00000267168	ENSP00000352182	ENSP00000466829	family with sequence similarity 86, member C1	Uncharacterized protein	0.551
FAM86C1	METTL21A	ENSP00000352182	ENSP00000385481	family with sequence similarity 86, member C1	methyltransferase like 21A; Protein-lysine methyltransferase	0.551
FAM86C1	METTL21C	ENSP00000352182	ENSP00000267273	family with sequence similarity 86, member C1	methyltransferase like 21C; Protein-lysine methyltransferase	0.551
METTL21A	FAM86A	ENSP00000385481	ENSP00000398502	methyltransferase like 21A; Protein-lysine methyltransferase	family with sequence similarity 86, member A	0.551
METTL21A	FAM86C1	ENSP00000385481	ENSP00000352182	methyltransferase like 21A; Protein-lysine methyltransferase	family with sequence similarity 86, member C1	0.551
METTL21A	METTL21C	ENSP00000385481	ENSP00000267273	methyltransferase like 21A; Protein-lysine methyltransferase	methyltransferase like 21C; Protein-lysine methyltransferase	0.419
METTL21C	FAM86A	ENSP00000267273	ENSP00000398502	methyltransferase like 21C; Protein-lysine methyltransferase	family with sequence similarity 86, member A	0.551
METTL21C	FAM86C1	ENSP00000267273	ENSP00000352182	methyltransferase like 21C; Protein-lysine methyltransferase	family with sequence similarity 86, member C1	0.551
METTL21C	METTL21A	ENSP00000267273	ENSP00000385481	methyltransferase like 21C; Protein-lysine methyltransferase	methyltransferase like 21A; Protein-lysine methyltransferase	0.419
PRTFDC1	FAM86A	ENSP00000318602	ENSP00000398502	phosphoribosyl transferase domain containing 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage	family with sequence similarity 86, member A	0.796
WBSCR22	WBSCR27	ENSP00000401191	ENSP00000297873	Williams Beuren syndrome chromosome region 22	Williams Beuren syndrome chromosome region 27	0.403
WBSCR27	WBSCR22	ENSP00000297873	ENSP00000401191	Williams Beuren syndrome chromosome region 27	Williams Beuren syndrome chromosome region 22	0.403

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