node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPN2 | CAPNS2 | ENSP00000295006 | ENSP00000400882 | calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | calpain, small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity | 0.591 |
CAPN2 | PDCD6IP | ENSP00000295006 | ENSP00000411825 | calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | programmed cell death 6 interacting protein; Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such [...] | 0.511 |
CAPN2 | PTPN23 | ENSP00000295006 | ENSP00000265562 | calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.561 |
CAPN2 | RHPN1 | ENSP00000295006 | ENSP00000289013 | calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | rhophilin, Rho GTPase binding protein 1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity) | 0.511 |
CAPN2 | RHPN2 | ENSP00000295006 | ENSP00000254260 | calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | rhophilin, Rho GTPase binding protein 2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity | 0.511 |
CAPNS2 | CAPN2 | ENSP00000400882 | ENSP00000295006 | calpain, small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity | calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | 0.591 |
CAPNS2 | SEC31A | ENSP00000400882 | ENSP00000347329 | calpain, small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity | SEC31 homolog A (S. cerevisiae) | 0.752 |
CAPNS2 | SEC31B | ENSP00000400882 | ENSP00000359370 | calpain, small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity | SEC31 homolog B (S. cerevisiae); As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum | 0.752 |
PDCD6IP | CAPN2 | ENSP00000411825 | ENSP00000295006 | programmed cell death 6 interacting protein; Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such [...] | calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | 0.511 |
PDCD6IP | PTPN23 | ENSP00000411825 | ENSP00000265562 | programmed cell death 6 interacting protein; Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such [...] | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.634 |
PTPN23 | CAPN2 | ENSP00000265562 | ENSP00000295006 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | 0.561 |
PTPN23 | PDCD6IP | ENSP00000265562 | ENSP00000411825 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | programmed cell death 6 interacting protein; Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such [...] | 0.634 |
RHPN1 | CAPN2 | ENSP00000289013 | ENSP00000295006 | rhophilin, Rho GTPase binding protein 1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity) | calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | 0.511 |
RHPN2 | CAPN2 | ENSP00000254260 | ENSP00000295006 | rhophilin, Rho GTPase binding protein 2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity | calpain 2, (m/II) large subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | 0.511 |
SEC31A | CAPNS2 | ENSP00000347329 | ENSP00000400882 | SEC31 homolog A (S. cerevisiae) | calpain, small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity | 0.752 |
SEC31A | SEC31B | ENSP00000347329 | ENSP00000359370 | SEC31 homolog A (S. cerevisiae) | SEC31 homolog B (S. cerevisiae); As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum | 0.905 |
SEC31B | CAPNS2 | ENSP00000359370 | ENSP00000400882 | SEC31 homolog B (S. cerevisiae); As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum | calpain, small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity | 0.752 |
SEC31B | SEC31A | ENSP00000359370 | ENSP00000347329 | SEC31 homolog B (S. cerevisiae); As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum | SEC31 homolog A (S. cerevisiae) | 0.905 |
TRIM4 | TRIM41 | ENSP00000348216 | ENSP00000320869 | tripartite motif containing 4 | tripartite motif containing 41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C | 0.461 |
TRIM41 | TRIM4 | ENSP00000320869 | ENSP00000348216 | tripartite motif containing 41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C | tripartite motif containing 4 | 0.461 |