Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
ERH ERH XYLB XYLB SHKBP1 SHKBP1 GLUD2 GLUD2 NAGS NAGS VPS4B VPS4B GLUD1 GLUD1 TOMM70A TOMM70A UBB UBB GLS GLS CAD CAD UBC UBC OTC OTC LRPPRC LRPPRC GLUL GLUL CPS1 CPS1 HSPA9 HSPA9 KIAA0368 KIAA0368 ACACB ACACB FH FH ACACA ACACA UPF2 UPF2 KCTD3 KCTD3 CPT1A CPT1A MRPS26 MRPS26 PCBP1 PCBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
OTCornithine carbamoyltransferase (354 aa)
XYLBxylulokinase homolog (H. influenzae); Phosphorylates D-xylulose to produce D-xylulose 5- phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis (536 aa)
VPS4Bvacuolar protein sorting 4 homolog B (S. cerevisiae); Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growt [...] (444 aa)
KCTD3potassium channel tetramerisation domain containing 3 (815 aa)
KIAA0368KIAA0368; Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis (2017 aa)
LRPPRCleucine-rich pentatricopeptide repeat containing; May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondria [...] (1394 aa)
CADcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa)
CPT1Acarnitine palmitoyltransferase 1A (liver); Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism (773 aa)
GLUD1glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) (558 aa)
TOMM70Atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity) (608 aa)
SHKBP1SH3KBP1 binding protein 1 (707 aa)
NAGSN-acetylglutamate synthase; Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity (534 aa)
HSPA9heat shock 70kDa protein 9 (mortalin) (679 aa)
UBBubiquitin B (229 aa)
PCBP1poly(rC) binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (356 aa)
GLULglutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts (373 aa)
GLSglutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity (669 aa)
GLUD2glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission (558 aa)
ACACBacetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
ACACAacetyl-CoA carboxylase alpha (2383 aa)
UBCubiquitin C (685 aa)
UPF2UPF2 regulator of nonsense transcripts homolog (yeast) (1272 aa)
FHfumarate hydratase; Also acts as a tumor suppressor (510 aa)
MRPS26mitochondrial ribosomal protein S26 (205 aa)
CPS1carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell (1506 aa)
ERHenhancer of rudimentary homolog (Drosophila); May have a role in the cell cycle (104 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (29%)