Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | CD97 | CD97 molecule; Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity) (835 aa) | ||
 | EMR3 | egf-like module containing, mucin-like, hormone receptor-like 3; Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes- derived macrophages and activated neutrophils (652 aa) | ||
 | GPR133 | G protein-coupled receptor 133; Orphan receptor (874 aa) | ||
 | FBN3 | fibrillin 3; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin- containing microfibrils provide long-term force bearing structural support (2809 aa) | ||
 | GPR114 | G protein-coupled receptor 114; Orphan receptor (528 aa) | ||
 | GPR111 | G protein-coupled receptor 111; Orphan receptor (708 aa) | ||
 | KLK1 | kallikrein 1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin (262 aa) | ||
 | GPR113 | G protein-coupled receptor 113 (1079 aa) | ||
 | EMR1 | egf-like module containing, mucin-like, hormone receptor-like 1 (886 aa) | ||
 | KLK2 | kallikrein-related peptidase 2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin (261 aa) | ||
 | KLK3 | kallikrein-related peptidase 3; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum (261 aa) | ||
 | FLNC | filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers (2725 aa) | ||
 | LPHN1 | latrophilin 1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity) (1474 aa) | ||
 | SORBS1 | sorbin and SH3 domain containing 1 (1292 aa) | ||
 | GPR126 | G protein-coupled receptor 126 (1250 aa) | ||
 | FLNA | filamin A, alpha; Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis (2647 aa) | ||
 | GPR112 | G protein-coupled receptor 112; Orphan receptor (3080 aa) | ||
 | ELTD1 | EGF, latrophilin and seven transmembrane domain containing 1; Could be involved in cardiac development (690 aa) | ||
 | GPR110 | G protein-coupled receptor 110 (910 aa) | ||
 | GPR56 | G protein-coupled receptor 56; Could be involved in cell-cell interactions (693 aa) | ||
 | GPR64 | G protein-coupled receptor 64 (1017 aa) | ||
 | TENM1 | teneurin transmembrane protein 1; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity) (2732 aa) | ||
 | MBD1 | methyl-CpG binding domain protein 1 (630 aa) | ||
 | FLNB | filamin B, beta (2633 aa) | ||
 | EMR2 | egf-like module containing, mucin-like, hormone receptor-like 2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF (823 aa) | ||
 | ENSG00000268550 | Uncharacterized protein (95 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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