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STRINGSTRING
MICAL1 MICAL1 SPTBN5 SPTBN5 SPTB SPTB MACF1 MACF1 SPTAN1 SPTAN1 SPTBN2 SPTBN2 SPTBN4 SPTBN4 PLEC PLEC SPTA1 SPTA1 SPTBN1 SPTBN1 MBD1 MBD1 SORBS1 SORBS1 SYNE2 SYNE2 TENM1 TENM1 FLNC FLNC FLNA FLNA FLNB FLNB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
SPTBN4spectrin, beta, non-erythrocytic 4 (2564 aa)
SPTBN2spectrin, beta, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton (2390 aa)
SPTBN5spectrin, beta, non-erythrocytic 5 (3674 aa)
PLECplectin (4684 aa)
FLNCfilamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers (2725 aa)
SPTBN1spectrin, beta, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane (2364 aa)
SYNE2spectrin repeat containing, nuclear envelope 2 (6907 aa)
MICAL1microtubule associated monoxygenase, calponin and LIM domain containing 1 (1067 aa)
MACF1microtubule-actin crosslinking factor 1 (5430 aa)
SORBS1sorbin and SH3 domain containing 1 (1292 aa)
SPTA1spectrin, alpha, erythrocytic 1 (elliptocytosis 2); Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2419 aa)
FLNAfilamin A, alpha; Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis (2647 aa)
SPTAN1spectrin, alpha, non-erythrocytic 1 (2477 aa)
SPTBspectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2328 aa)
TENM1teneurin transmembrane protein 1; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity) (2732 aa)
MBD1methyl-CpG binding domain protein 1 (630 aa)
FLNBfilamin B, beta (2633 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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