13 items (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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Your Input:
	KIAA0368	KIAA0368; Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis (2017 aa)
	HLA-F	major histocompatibility complex, class I, F (442 aa)
	TYK2	tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain (1187 aa)
	HLA-G	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells (338 aa)
	CEP170	centrosomal protein 170kDa; Plays a role in microtubule organization (1584 aa)
	MR1	major histocompatibility complex, class I-related (341 aa)
	PCGF6	polycomb group ring finger 6; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility (350 aa)
	PRKAA2	protein kinase, AMP-activated, alpha 2 catalytic subunit; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as [...] (552 aa)
	HLA-C	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) (366 aa)
	HLA-A	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity) (365 aa)
	KIF2A	kinesin heavy chain member 2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (744 aa)
	HLA-B	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity) (362 aa)
	KIAA0284	KIAA0284; Plays a role in microtubule organization (By similarity) (1554 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEP170	KIF2A	ENSP00000355500	ENSP00000385000	centrosomal protein 170kDa; Plays a role in microtubule organization	kinesin heavy chain member 2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity	0.485
HLA-A	HLA-B	ENSP00000366005	ENSP00000399168	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.901
HLA-A	HLA-C	ENSP00000366005	ENSP00000365402	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-A	HLA-G	ENSP00000366005	ENSP00000353472	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.544
HLA-A	MR1	ENSP00000366005	ENSP00000356552	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I-related	0.559
HLA-B	HLA-A	ENSP00000399168	ENSP00000366005	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.901
HLA-B	HLA-C	ENSP00000399168	ENSP00000365402	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-B	HLA-G	ENSP00000399168	ENSP00000353472	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.546
HLA-B	MR1	ENSP00000399168	ENSP00000356552	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I-related	0.560
HLA-C	HLA-A	ENSP00000365402	ENSP00000366005	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-C	HLA-B	ENSP00000365402	ENSP00000399168	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.900
HLA-C	HLA-G	ENSP00000365402	ENSP00000353472	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	0.545
HLA-C	MR1	ENSP00000365402	ENSP00000356552	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	major histocompatibility complex, class I-related	0.543
HLA-G	HLA-A	ENSP00000353472	ENSP00000366005	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.544
HLA-G	HLA-B	ENSP00000353472	ENSP00000399168	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	major histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.546
HLA-G	HLA-C	ENSP00000353472	ENSP00000365402	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	major histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.545
HLA-G	MR1	ENSP00000353472	ENSP00000356552	major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells	major histocompatibility complex, class I-related	0.561
KIAA0284	PRKAA2	ENSP00000404151	ENSP00000360290	KIAA0284; Plays a role in microtubule organization (By similarity)	protein kinase, AMP-activated, alpha 2 catalytic subunit; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as [...]	0.632
KIF2A	CEP170	ENSP00000385000	ENSP00000355500	kinesin heavy chain member 2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity	centrosomal protein 170kDa; Plays a role in microtubule organization	0.485
MR1	HLA-A	ENSP00000356552	ENSP00000366005	major histocompatibility complex, class I-related	major histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity)	0.559

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