Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
||||
 | NME4 | NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity) (187 aa) | ||
 | RNF103 | ring finger protein 103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway (685 aa) | ||
 | RNF11 | ring finger protein 11; Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates ’Lys-63’ polyubiquitin chains on RIPK1 and catalyzes the formation of ’Lys-48’-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leadi [...] (154 aa) | ||
 | COQ9 | coenzyme Q9 homolog (S. cerevisiae); Involved in the biosynthesis of coenzyme Q (By similarity) (318 aa) | ||
 | RNF165 | ring finger protein 165 (346 aa) | ||
 | RNF44 | ring finger protein 44 (432 aa) | ||
 | RNF111 | ring finger protein 111 (986 aa) | ||
 | RNF126 | ring finger protein 126 (311 aa) | ||
 | ZSWIM2 | zinc finger, SWIM-type containing 2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes (By similarity) (633 aa) | ||
 | RNF149 | ring finger protein 149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation (400 aa) | ||
 | C7orf55 | chromosome 7 open reading frame 55 (113 aa) | ||
 | TRMT10C | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends (403 aa) | ||
 | RNF32 | ring finger protein 32; May play a role in sperm formation (362 aa) | ||
 | XPNPEP3 | X-prolyl aminopeptidase (aminopeptidase P) 3, putative (507 aa) | ||
 | PJA1 | praja ring finger 1, E3 ubiquitin protein ligase; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting (643 aa) | ||
 | RNF115 | ring finger protein 115; Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking (304 aa) | ||
 | LYRM5 | LYR motif containing 5 (90 aa) | ||
 | RNF215 | ring finger protein 215 (377 aa) | ||
 | RNF43 | ring finger protein 43; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (783 aa) | ||
 | RNF24 | ring finger protein 24; May play a role in TRPCs intracellular trafficking (169 aa) | ||
 | CISD3 | CDGSH iron sulfur domain 3 (127 aa) | ||
 | ENSG00000249884 | RNF103-CHMP3 readthrough (221 aa) | ||
 | CHMP3 | charged multivesicular body protein 3 (251 aa) | ||
 | NT5DC2 | 5’-nucleotidase domain containing 2 (557 aa) | ||
 | RNF150 | ring finger protein 150 (438 aa) | ||
 | RNF130 | ring finger protein 130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin- protein ligase (419 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
