node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NT5DC2 | TOLLIP | ENSP00000406933 | ENSP00000314733 | 5’-nucleotidase domain containing 2 | toll interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity | 0.456 |
NT5DC2 | TRMT10C | ENSP00000406933 | ENSP00000312356 | 5’-nucleotidase domain containing 2 | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends | 0.551 |
NT5DC2 | UBC | ENSP00000406933 | ENSP00000344818 | 5’-nucleotidase domain containing 2 | ubiquitin C | 0.483 |
RNF115 | UBC | ENSP00000358297 | ENSP00000344818 | ring finger protein 115; Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking | ubiquitin C | 0.997 |
RNF122 | UBC | ENSP00000256257 | ENSP00000344818 | ring finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability | ubiquitin C | 0.826 |
RNF149 | UBC | ENSP00000295317 | ENSP00000344818 | ring finger protein 149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation | ubiquitin C | 0.909 |
RNF44 | UBC | ENSP00000274811 | ENSP00000344818 | ring finger protein 44 | ubiquitin C | 0.678 |
TERF2 | UBC | ENSP00000254942 | ENSP00000344818 | telomeric repeat binding factor 2; Binds the telomeric double-stranded 5’-TTAGGG-3’ repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5’-TTAGGG-3’ repeats added b [...] | ubiquitin C | 0.982 |
TOLLIP | NT5DC2 | ENSP00000314733 | ENSP00000406933 | toll interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity | 5’-nucleotidase domain containing 2 | 0.456 |
TOLLIP | UBC | ENSP00000314733 | ENSP00000344818 | toll interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity | ubiquitin C | 0.999 |
TRAF1 | TRAF2 | ENSP00000362994 | ENSP00000247668 | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 | TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes ’Lys-63’- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein level [...] | 0.999 |
TRAF1 | UBC | ENSP00000362994 | ENSP00000344818 | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 | ubiquitin C | 0.804 |
TRAF2 | TRAF1 | ENSP00000247668 | ENSP00000362994 | TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes ’Lys-63’- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein level [...] | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 | 0.999 |
TRAF2 | UBC | ENSP00000247668 | ENSP00000344818 | TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes ’Lys-63’- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein level [...] | ubiquitin C | 0.999 |
TRMT10C | NT5DC2 | ENSP00000312356 | ENSP00000406933 | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends | 5’-nucleotidase domain containing 2 | 0.551 |
TRMT10C | UBC | ENSP00000312356 | ENSP00000344818 | tRNA methyltransferase 10 homolog C (S. cerevisiae); Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5’-ends | ubiquitin C | 0.620 |
TSG101 | UBC | ENSP00000251968 | ENSP00000344818 | tumor susceptibility gene 101; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P [...] | ubiquitin C | 0.999 |
UBC | NT5DC2 | ENSP00000344818 | ENSP00000406933 | ubiquitin C | 5’-nucleotidase domain containing 2 | 0.483 |
UBC | RNF115 | ENSP00000344818 | ENSP00000358297 | ubiquitin C | ring finger protein 115; Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking | 0.997 |
UBC | RNF122 | ENSP00000344818 | ENSP00000256257 | ubiquitin C | ring finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability | 0.826 |