node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GRAP2 | GRB7 | ENSP00000339186 | ENSP00000403459 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | growth factor receptor-bound protein 7 | 0.920 |
GRAP2 | LAX1 | ENSP00000339186 | ENSP00000406970 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | 0.701 |
GRAP2 | LCK | ENSP00000339186 | ENSP00000337825 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | lymphocyte-specific protein tyrosine kinase | 0.945 |
GRAP2 | SYK | ENSP00000339186 | ENSP00000364898 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.983 |
GRAP2 | UBC | ENSP00000339186 | ENSP00000344818 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | ubiquitin C | 0.527 |
GRAP2 | ZAP70 | ENSP00000339186 | ENSP00000264972 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...] | 0.975 |
GRB2 | GRB7 | ENSP00000339007 | ENSP00000403459 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | growth factor receptor-bound protein 7 | 0.917 |
GRB2 | LAX1 | ENSP00000339007 | ENSP00000406970 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | 0.623 |
GRB2 | LCK | ENSP00000339007 | ENSP00000337825 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | lymphocyte-specific protein tyrosine kinase | 0.942 |
GRB2 | SYK | ENSP00000339007 | ENSP00000364898 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...] | 0.999 |
GRB2 | UBC | ENSP00000339007 | ENSP00000344818 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | ubiquitin C | 0.949 |
GRB2 | ZAP70 | ENSP00000339007 | ENSP00000264972 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...] | 0.882 |
GRB7 | GRAP2 | ENSP00000403459 | ENSP00000339186 | growth factor receptor-bound protein 7 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.920 |
GRB7 | GRB2 | ENSP00000403459 | ENSP00000339007 | growth factor receptor-bound protein 7 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.917 |
GRB7 | LAX1 | ENSP00000403459 | ENSP00000406970 | growth factor receptor-bound protein 7 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | 0.557 |
LAX1 | GRAP2 | ENSP00000406970 | ENSP00000339186 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.701 |
LAX1 | GRB2 | ENSP00000406970 | ENSP00000339007 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.623 |
LAX1 | GRB7 | ENSP00000406970 | ENSP00000403459 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | growth factor receptor-bound protein 7 | 0.557 |
LAX1 | LCK | ENSP00000406970 | ENSP00000337825 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | lymphocyte-specific protein tyrosine kinase | 0.634 |
LAX1 | STAMBPL1 | ENSP00000406970 | ENSP00000360992 | lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells | STAM binding protein-like 1; Zinc metalloprotease that specifically cleaves ’Lys-63’- linked polyubiquitin chains. Does not cleave ’Lys-48’-linked polyubiquitin chains | 0.516 |