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SART3 SART3 EDC4 EDC4 PATL1 PATL1 NAA38 NAA38 DCP2 DCP2 LSM2 LSM2 LSM3 LSM3 PRPF8 PRPF8 LSM6 LSM6 SNRPD1 SNRPD1 LSM4 LSM4 LSM7 LSM7 PRPF6 PRPF6 SART1 SART1 SNRPD2 SNRPD2 LSM1 LSM1 RMI2 RMI2 LSM5 LSM5 PRPF4 PRPF4 WDR69 WDR69 PRPF3 PRPF3 CRNKL1 CRNKL1 SNRPD3 SNRPD3 SNRPF SNRPF MIF4GD MIF4GD GTF2B GTF2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
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SNRPD3small nuclear ribonucleoprotein D3 polypeptide 18kDa; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner (126 aa)
SART3squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication (963 aa)
MIF4GDMIF4G domain containing; Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (256 aa)
NAA38N(alpha)-acetyltransferase 38, NatC auxiliary subunit; Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome (96 aa)
LSM7LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA and is probably a component of the spliceosome (103 aa)
PRPF6PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) (941 aa)
SNRPFsmall nuclear ribonucleoprotein polypeptide F; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Associated with snRNP U1, U2, U4/U6 and U5 (86 aa)
LSM6LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae); Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5’-to-3’ mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing [...] (80 aa)
PATL1protein associated with topoisomerase II homolog 1 (yeast); RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV) (770 aa)
SNRPD1small nuclear ribonucleoprotein D1 polypeptide 16kDa; May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA (119 aa)
LSM3LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA (102 aa)
PRPF8PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site (2335 aa)
RMI2RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae); Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress- induced nuclear foci and mitotic phosphorylation of BLM (147 aa)
SART1squamous cell carcinoma antigen recognized by T cells; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA (800 aa)
LSM1LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA (133 aa)
WDR69WD repeat domain 69; May play a role in axonemal outer row dynein assembly (By similarity) (415 aa)
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) (683 aa)
SNRPD2small nuclear ribonucleoprotein D2 polypeptide 16.5kDa; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity) (118 aa)
EDC4enhancer of mRNA decapping 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro) (1401 aa)
GTF2Bgeneral transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II (316 aa)
PRPF4PRP4 pre-mRNA processing factor 4 homolog (yeast); Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (522 aa)
LSM2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) (95 aa)
CRNKL1crooked neck pre-mRNA splicing factor-like 1 (Drosophila) (848 aa)
DCP2DCP2 decapping enzyme homolog (S. cerevisiae); Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety (420 aa)
LSM5LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in U6 snRNP assembly and function. Binds to the 3’ end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex formation in vitro (91 aa)
LSM4LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); Binds specifically to the 3’-terminal U-tract of U6 snRNA (139 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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