node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP1M1 | AP2M1 | ENSP00000388996 | ENSP00000292807 | adaptor-related protein complex 1, mu 1 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] | 0.409 |
AP1M1 | RUNDC3A | ENSP00000388996 | ENSP00000410862 | adaptor-related protein complex 1, mu 1 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.410 |
AP2M1 | AP1M1 | ENSP00000292807 | ENSP00000388996 | adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] | adaptor-related protein complex 1, mu 1 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.409 |
CCNL2 | RUNDC3A | ENSP00000383611 | ENSP00000410862 | cyclin L2 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.493 |
EIF3E | RUNDC3A | ENSP00000220849 | ENSP00000410862 | eukaryotic translation initiation factor 3, subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.725 |
MRPL15 | RUNDC3A | ENSP00000260102 | ENSP00000410862 | mitochondrial ribosomal protein L15 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.554 |
RAP1A | RUNDC3A | ENSP00000348786 | ENSP00000410862 | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.617 |
RAP2A | RUNDC3A | ENSP00000245304 | ENSP00000410862 | RAP2A, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.800 |
RAP2B | RUNDC3A | ENSP00000319096 | ENSP00000410862 | RAP2B, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.727 |
RUNDC3A | AP1M1 | ENSP00000410862 | ENSP00000388996 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | adaptor-related protein complex 1, mu 1 subunit; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules | 0.410 |
RUNDC3A | CCNL2 | ENSP00000410862 | ENSP00000383611 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | cyclin L2 | 0.493 |
RUNDC3A | EIF3E | ENSP00000410862 | ENSP00000220849 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | eukaryotic translation initiation factor 3, subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.725 |
RUNDC3A | MRPL15 | ENSP00000410862 | ENSP00000260102 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | mitochondrial ribosomal protein L15 | 0.554 |
RUNDC3A | RAP1A | ENSP00000410862 | ENSP00000348786 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | 0.617 |
RUNDC3A | RAP2A | ENSP00000410862 | ENSP00000245304 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | RAP2A, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading | 0.800 |
RUNDC3A | RAP2B | ENSP00000410862 | ENSP00000319096 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | RAP2B, member of RAS oncogene family; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells | 0.727 |
RUNDC3A | TFPT | ENSP00000410862 | ENSP00000375639 | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | TCF3 (E2A) fusion partner (in childhood Leukemia) | 0.410 |
TFPT | RUNDC3A | ENSP00000375639 | ENSP00000410862 | TCF3 (E2A) fusion partner (in childhood Leukemia) | RUN domain containing 3A; May act as an effector of RAP2A in neuronal cells (By similarity) | 0.410 |