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ENSG00000258728 ENSG00000258728 CNTFR CNTFR IL6ST IL6ST LIFR LIFR CSF2RB CSF2RB GHR GHR IL2RB IL2RB IL7R IL7R IL22RA2 IL22RA2 JAK1 JAK1 IL20RB IL20RB IL23R IL23R IL10 IL10 CRTAM CRTAM IL10RA IL10RA IL10RB IL10RB GATA3 GATA3 IFNAR1 IFNAR1 STAT6 STAT6 IFNGR1 IFNGR1 MAP3K5 MAP3K5 SMAD3 SMAD3 JUNB JUNB JUN JUN SMAD4 SMAD4 A2M A2M
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
IL2RBinterleukin 2 receptor, beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2 (551 aa)
CRTAMcytotoxic and regulatory T cell molecule; Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo (393 aa)
IL10RAinterleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity (578 aa)
GHRgrowth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity) (638 aa)
CNTFRciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity (372 aa)
LIFRleukemia inhibitory factor receptor alpha; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells (1097 aa)
IFNAR1interferon (alpha, beta and omega) receptor 1; Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves (557 aa)
IL10RBinterleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 (325 aa)
IL22RA2interleukin 22 receptor, alpha 2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses (263 aa)
STAT6signal transducer and activator of transcription 6, interleukin-4 induced; Carries out a dual function- signal transduction and activation of transcription. Involved in interleukin-4 signalling (847 aa)
JUNBjun B proto-oncogene; Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5’-TGA[CG]TCA-3’ (347 aa)
IL7Rinterleukin 7 receptor (459 aa)
IL23Rinterleukin 23 receptor (629 aa)
A2Malpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ’bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the co [...] (1474 aa)
IL20RBinterleukin 20 receptor beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24 (311 aa)
SMAD3SMAD family member 3 (425 aa)
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor); Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events (918 aa)
SMAD4SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] (552 aa)
JAK1Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor (1154 aa)
MAP3K5mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] (1374 aa)
IFNGR1interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer (489 aa)
JUNjun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (331 aa)
GATA3GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ (444 aa)
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor (897 aa)
IL10interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells (178 aa)
ENSG00000258728Uncharacterized protein (280 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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