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GSK3A | glycogen synthase kinase 3 alpha; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. M [...] (483 aa) | |||
PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4; Synthesis and degradation of fructose 2,6-bisphosphate (469 aa) | |||
EIF5A2 | eukaryotic translation initiation factor 5A2; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By si [...] (153 aa) | |||
GSK3B | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] (433 aa) | |||
EIF5A | eukaryotic translation initiation factor 5A; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an importa [...] (184 aa) | |||
LIMK2 | LIM domain kinase 2; Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (686 aa) | |||
SMYD2 | SET and MYND domain containing 2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 ’Lys-4’ (H3K4me) and dimethylates histone H3 ’Lys-36’ (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates ’Lys-370’ of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates ’Lys-860’ of RB1/RB (433 aa) | |||
PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate (505 aa) | |||
DSTYK | dual serine/threonine and tyrosine protein kinase (929 aa) | |||
PEX19 | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (299 aa) | |||
BAG3 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity (575 aa) | |||
PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; Synthesis and degradation of fructose 2,6-bisphosphate (471 aa) | |||
PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; Synthesis and degradation of fructose 2,6-bisphosphate (520 aa) | |||
EXT2 | exostosin 2; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor (751 aa) | |||
GSKIP | GSK3B interacting protein (139 aa) | |||
BAG1 | BCL2-associated athanogene (345 aa) | |||
EIF5AL1 | eukaryotic translation initiation factor 5A-like 1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation [...] (154 aa) | |||
ENSG00000268643 | Uncharacterized protein (167 aa) |