node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AURKA | UBC | ENSP00000216911 | ENSP00000344818 | aurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] | ubiquitin C | 0.999 |
HECTD1 | TCEAL4 | ENSP00000382269 | ENSP00000415564 | HECT domain containing E3 ubiquitin protein ligase 1; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity) | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | 0.404 |
HECTD1 | UBC | ENSP00000382269 | ENSP00000344818 | HECT domain containing E3 ubiquitin protein ligase 1; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity) | ubiquitin C | 0.998 |
HECTD1 | USP11 | ENSP00000382269 | ENSP00000218348 | HECT domain containing E3 ubiquitin protein ligase 1; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity) | ubiquitin specific peptidase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks | 0.504 |
P4HB | TCEAL4 | ENSP00000327801 | ENSP00000415564 | prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...] | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | 0.538 |
P4HB | UBA2 | ENSP00000327801 | ENSP00000246548 | prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...] | ubiquitin-like modifier activating enzyme 2; The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 | 0.474 |
P4HB | UBC | ENSP00000327801 | ENSP00000344818 | prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...] | ubiquitin C | 0.963 |
TCEAL1 | TCEAL2 | ENSP00000361707 | ENSP00000332359 | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | 0.999 |
TCEAL1 | TCEAL4 | ENSP00000361707 | ENSP00000415564 | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | 0.999 |
TCEAL1 | USP11 | ENSP00000361707 | ENSP00000218348 | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | ubiquitin specific peptidase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks | 0.943 |
TCEAL1 | USP7 | ENSP00000361707 | ENSP00000343535 | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | ubiquitin specific peptidase 7 (herpes virus-associated); Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53- dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen pero [...] | 0.891 |
TCEAL2 | TCEAL1 | ENSP00000332359 | ENSP00000361707 | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | 0.999 |
TCEAL2 | TCEAL4 | ENSP00000332359 | ENSP00000415564 | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | 0.999 |
TCEAL2 | UBC | ENSP00000332359 | ENSP00000344818 | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | ubiquitin C | 0.721 |
TCEAL2 | USP11 | ENSP00000332359 | ENSP00000218348 | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | ubiquitin specific peptidase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks | 0.891 |
TCEAL4 | HECTD1 | ENSP00000415564 | ENSP00000382269 | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | HECT domain containing E3 ubiquitin protein ligase 1; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity) | 0.404 |
TCEAL4 | P4HB | ENSP00000415564 | ENSP00000327801 | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | prolyl 4-hydroxylase, beta polypeptide; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with [...] | 0.538 |
TCEAL4 | TCEAL1 | ENSP00000415564 | ENSP00000361707 | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | transcription elongation factor A (SII)-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly | 0.999 |
TCEAL4 | TCEAL2 | ENSP00000415564 | ENSP00000332359 | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | transcription elongation factor A (SII)-like 2; May be involved in transcriptional regulation | 0.999 |
TCEAL4 | UBA2 | ENSP00000415564 | ENSP00000246548 | transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation | ubiquitin-like modifier activating enzyme 2; The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 | 0.414 |