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STRINGSTRING
ISL2 ISL2 KSR2 KSR2 RHOXF2B RHOXF2B LHX5 LHX5 ISL1 ISL1 LHX1 LHX1 RHOXF2 RHOXF2 LBX2 LBX2 DMBX1 DMBX1 OTP OTP LMX1A LMX1A RHOXF1 RHOXF1 UNCX UNCX ALX1 ALX1 ALX3 ALX3 LHX9 LHX9 LHX2 LHX2 HOPX HOPX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RHOXF1Rhox homeobox family, member 1; May be a transcription factor involved in reproductive processes (184 aa)
ISL1ISL LIM homeobox 1; Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) (349 aa)
LHX1LIM homeobox 1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (406 aa)
LHX5LIM homeobox 5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system (402 aa)
ISL2ISL LIM homeobox 2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways (By similarity) (359 aa)
LMX1ALIM homeobox transcription factor 1, alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity) (382 aa)
OTPorthopedia homeobox; Probably involved in the differentiation of hypothalamic neuroendocrine cells (325 aa)
UNCXUNC homeobox; Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions (By similarity) (531 aa)
ALX1ALX homeobox 1; Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development (326 aa)
KSR2kinase suppressor of ras 2; Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production (950 aa)
DMBX1diencephalon/mesencephalon homeobox 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5’-TAATCCGATTA-3’) sequence. Required for brain development (By similarity) (377 aa)
LHX9LIM homeobox 9; Involved in gonadal development (By similarity) (397 aa)
ALX3ALX homeobox 3; Transcriptional regulator with a possible role in patterning of mesoderm during development (By similarity) (343 aa)
RHOXF2Rhox homeobox family, member 2 (288 aa)
RHOXF2BRhox homeobox family, member 2B (288 aa)
LHX2LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) (406 aa)
LBX2ladybird homeobox 2; Putative transcription factor (By similarity) (194 aa)
HOPXHOP homeobox; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor (112 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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