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STRINGSTRING
CSNK2A2 CSNK2A2 NVL NVL GNL3L GNL3L RRP1 RRP1 NIP7 NIP7 NSUN6 NSUN6 NOC2L NOC2L GTPBP4 GTPBP4 DDX54 DDX54 CEBPZ CEBPZ DDX55 DDX55 PES1 PES1 BRIX1 BRIX1 WDR74 WDR74 MKI67IP MKI67IP RPL3L RPL3L RPF2 RPF2 DDX27 DDX27 RPF1 RPF1 NOP2 NOP2 UBC UBC WDR12 WDR12 EIF6 EIF6 MRTO4 MRTO4 RPL3 RPL3 GNL3 GNL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CEBPZCCAAT/enhancer binding protein (C/EBP), zeta; Stimulates transcription from the HSP70 promoter (1054 aa)
DDX55DEAD (Asp-Glu-Ala-Asp) box polypeptide 55; Probable ATP-binding RNA helicase (600 aa)
NIP7nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly (180 aa)
WDR12WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (423 aa)
CSNK2A2casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] (350 aa)
RPL3Lribosomal protein L3-like (407 aa)
WDR74WD repeat domain 74 (385 aa)
NVLnuclear VCP-like (856 aa)
MKI67IPMKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa)
NOC2Lnucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter (749 aa)
DDX54DEAD (Asp-Glu-Ala-Asp) box polypeptide 54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (882 aa)
GNL3Lguanine nucleotide binding protein-like 3 (nucleolar)-like; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal pr [...] (582 aa)
BRIX1BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit (353 aa)
UBCubiquitin C (685 aa)
RPL3ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes (403 aa)
PES1pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome (588 aa)
GTPBP4GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) (634 aa)
RPF1ribosome production factor 1 homolog (S. cerevisiae); May be required for ribosome biogenesis (349 aa)
DDX27DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (796 aa)
EIF6eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity (245 aa)
MRTO4mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) (239 aa)
NSUN6NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) (469 aa)
NOP2NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase (808 aa)
GNL3guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity) (549 aa)
RPF2ribosome production factor 2 homolog (S. cerevisiae) (306 aa)
RRP1ribosomal RNA processing 1 homolog (S. cerevisiae); Plays a critical role in the generation of 28S rRNA (461 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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