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STRINGSTRING
CECR2 CECR2 ENSG00000267261 ENSG00000267261 HIST1H4G HIST1H4G HIST1H4L HIST1H4L HIST1H4J HIST1H4J DACH1 DACH1 HIST1H4K HIST1H4K HIST2H4B HIST2H4B HIST1H4I HIST1H4I HIST2H4A HIST2H4A ASH1L ASH1L BRD1 BRD1 BRPF3 BRPF3 HIST1H4B HIST1H4B KAT2A KAT2A HIST4H4 HIST4H4 HIST1H4F HIST1H4F HIST1H4H HIST1H4H KAT2B KAT2B HIST1H4A HIST1H4A HIST1H4D HIST1H4D HIST1H4E HIST1H4E HIST1H4C HIST1H4C TSPYL6 TSPYL6 DACH2 DACH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
BRD1bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (1058 aa)
KAT2AK(lysine) acetyltransferase 2A; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat’s transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (837 aa)
HIST1H4Ghistone cluster 1, H4g; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity) (98 aa)
CECR2cat eye syndrome chromosome region, candidate 2; Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (1443 aa)
KAT2BK(lysine) acetyltransferase 2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat’s transactivating activity and may help inducing chromatin remodeling of proviral genes (832 aa)
HIST1H4Hhistone cluster 1, H4h (103 aa)
DACH1dachshund homolog 1 (Drosophila) (708 aa)
HIST1H4Dhistone cluster 1, H4d (103 aa)
HIST1H4Ihistone cluster 1, H4i (103 aa)
HIST1H4Jhistone cluster 1, H4j (103 aa)
HIST1H4Lhistone cluster 1, H4l (103 aa)
HIST1H4Khistone cluster 1, H4k (103 aa)
BRPF3bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (1205 aa)
HIST4H4histone cluster 4, H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (103 aa)
HIST1H4Ahistone cluster 1, H4a (103 aa)
HIST1H4Ehistone cluster 1, H4e (103 aa)
HIST2H4Bhistone cluster 2, H4b (103 aa)
HIST2H4Ahistone cluster 2, H4a (103 aa)
DACH2dachshund homolog 2 (Drosophila); Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by [...] (599 aa)
HIST1H4Bhistone cluster 1, H4b (103 aa)
HIST1H4Fhistone cluster 1, H4f (103 aa)
HIST1H4Chistone cluster 1, H4c (103 aa)
ASH1Lash1 (absent, small, or homeotic)-like (Drosophila); Histone methyltransferase specifically methylating ’Lys- 36’ of histone H3 (H3K36me) (2964 aa)
TSPYL6TSPY-like 6 (410 aa)
ENSG00000267261Ras-related protein Rab-5C (282 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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