node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHCHD4 | CMC1 | ENSP00000295767 | ENSP00000418348 | coiled-coil-helix-coiled-coil-helix domain containing 4; Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contain [...] | COX assembly mitochondrial protein 1 homolog (S. cerevisiae); Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration (By similarity) | 0.977 |
CHCHD4 | GFER | ENSP00000295767 | ENSP00000248114 | coiled-coil-helix-coiled-coil-helix domain containing 4; Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contain [...] | growth factor, augmenter of liver regeneration; Isoform 1- FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen | 0.999 |
CMC1 | CHCHD4 | ENSP00000418348 | ENSP00000295767 | COX assembly mitochondrial protein 1 homolog (S. cerevisiae); Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration (By similarity) | coiled-coil-helix-coiled-coil-helix domain containing 4; Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contain [...] | 0.977 |
CMC1 | CMC2 | ENSP00000418348 | ENSP00000219400 | COX assembly mitochondrial protein 1 homolog (S. cerevisiae); Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration (By similarity) | COX assembly mitochondrial protein 2 homolog (S. cerevisiae); May be involved in cytochrome c oxidase biogenesis (By similarity) | 0.992 |
CMC1 | GFER | ENSP00000418348 | ENSP00000248114 | COX assembly mitochondrial protein 1 homolog (S. cerevisiae); Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration (By similarity) | growth factor, augmenter of liver regeneration; Isoform 1- FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen | 0.548 |
CMC2 | CMC1 | ENSP00000219400 | ENSP00000418348 | COX assembly mitochondrial protein 2 homolog (S. cerevisiae); May be involved in cytochrome c oxidase biogenesis (By similarity) | COX assembly mitochondrial protein 1 homolog (S. cerevisiae); Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration (By similarity) | 0.992 |
COA3 | MT-CO1 | ENSP00000354762 | ENSP00000354499 | cytochrome c oxidase assembly factor 3; Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly | mitochondrially encoded cytochrome c oxidase I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity) | 0.571 |
GFER | CHCHD4 | ENSP00000248114 | ENSP00000295767 | growth factor, augmenter of liver regeneration; Isoform 1- FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen | coiled-coil-helix-coiled-coil-helix domain containing 4; Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contain [...] | 0.999 |
GFER | CMC1 | ENSP00000248114 | ENSP00000418348 | growth factor, augmenter of liver regeneration; Isoform 1- FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen | COX assembly mitochondrial protein 1 homolog (S. cerevisiae); Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration (By similarity) | 0.548 |
MT-CO1 | COA3 | ENSP00000354499 | ENSP00000354762 | mitochondrially encoded cytochrome c oxidase I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity) | cytochrome c oxidase assembly factor 3; Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly | 0.571 |
MT-CO1 | SLC25A5 | ENSP00000354499 | ENSP00000360671 | mitochondrially encoded cytochrome c oxidase I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity) | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | 0.419 |
SLC25A5 | MT-CO1 | ENSP00000360671 | ENSP00000354499 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | mitochondrially encoded cytochrome c oxidase I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity) | 0.419 |