node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000263620 | SNAP25 | ENSP00000464383 | ENSP00000254976 | Uncharacterized protein | synaptosomal-associated protein, 25kDa | 0.927 |
ENSG00000263620 | SYNPR | ENSP00000464383 | ENSP00000418994 | Uncharacterized protein | synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity) | 0.583 |
ENSG00000263620 | SYT1 | ENSP00000464383 | ENSP00000261205 | Uncharacterized protein | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.907 |
FATE1 | SYNGR1 | ENSP00000359375 | ENSP00000332287 | fetal and adult testis expressed 1 | synaptogyrin 1; Involved in the regulation of short-term and long-term synaptic plasticity (By similarity) | 0.400 |
FATE1 | SYNPR | ENSP00000359375 | ENSP00000418994 | fetal and adult testis expressed 1 | synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity) | 0.400 |
GRIA1 | GRIN1 | ENSP00000285900 | ENSP00000360608 | glutamate receptor, ionotropic, AMPA 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a [...] | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.819 |
GRIA1 | VAMP2 | ENSP00000285900 | ENSP00000314214 | glutamate receptor, ionotropic, AMPA 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a [...] | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.403 |
GRIN1 | GRIA1 | ENSP00000360608 | ENSP00000285900 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | glutamate receptor, ionotropic, AMPA 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a [...] | 0.819 |
SNAP25 | ENSG00000263620 | ENSP00000254976 | ENSP00000464383 | synaptosomal-associated protein, 25kDa | Uncharacterized protein | 0.927 |
SNAP25 | SNCA | ENSP00000254976 | ENSP00000338345 | synaptosomal-associated protein, 25kDa | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.464 |
SNAP25 | SYT1 | ENSP00000254976 | ENSP00000261205 | synaptosomal-associated protein, 25kDa | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.997 |
SNAP25 | VAMP1 | ENSP00000254976 | ENSP00000379602 | synaptosomal-associated protein, 25kDa | vesicle-associated membrane protein 1 (synaptobrevin 1); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.883 |
SNAP25 | VAMP2 | ENSP00000254976 | ENSP00000314214 | synaptosomal-associated protein, 25kDa | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.999 |
SNAP25 | VAMP3 | ENSP00000254976 | ENSP00000054666 | synaptosomal-associated protein, 25kDa | vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | 0.876 |
SNCA | SNAP25 | ENSP00000338345 | ENSP00000254976 | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | synaptosomal-associated protein, 25kDa | 0.464 |
SYNGR1 | FATE1 | ENSP00000332287 | ENSP00000359375 | synaptogyrin 1; Involved in the regulation of short-term and long-term synaptic plasticity (By similarity) | fetal and adult testis expressed 1 | 0.400 |
SYNGR1 | SYNPR | ENSP00000332287 | ENSP00000418994 | synaptogyrin 1; Involved in the regulation of short-term and long-term synaptic plasticity (By similarity) | synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity) | 0.872 |
SYNGR1 | SYT1 | ENSP00000332287 | ENSP00000261205 | synaptogyrin 1; Involved in the regulation of short-term and long-term synaptic plasticity (By similarity) | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.578 |
SYNPR | ENSG00000263620 | ENSP00000418994 | ENSP00000464383 | synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity) | Uncharacterized protein | 0.583 |
SYNPR | FATE1 | ENSP00000418994 | ENSP00000359375 | synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity) | fetal and adult testis expressed 1 | 0.400 |