node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CALM2 | MALSU1 | ENSP00000272298 | ENSP00000419370 | calmodulin 2 (phosphorylase kinase, delta) | mitochondrial assembly of ribosomal large subunit 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome | 0.436 |
CALM2 | UBC | ENSP00000272298 | ENSP00000344818 | calmodulin 2 (phosphorylase kinase, delta) | ubiquitin C | 0.978 |
CHMP2B | UBC | ENSP00000263780 | ENSP00000344818 | charged multivesicular body protein 2B; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | ubiquitin C | 0.946 |
DCTD | MALSU1 | ENSP00000349576 | ENSP00000419370 | dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase | mitochondrial assembly of ribosomal large subunit 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome | 0.608 |
DCTD | UBC | ENSP00000349576 | ENSP00000344818 | dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase | ubiquitin C | 0.483 |
EIF1AX | RPL23 | ENSP00000368927 | ENSP00000377865 | eukaryotic translation initiation factor 1A, X-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits | ribosomal protein L23 | 0.966 |
EIF1AX | UBC | ENSP00000368927 | ENSP00000344818 | eukaryotic translation initiation factor 1A, X-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits | ubiquitin C | 0.837 |
EIF1AY | RPL23 | ENSP00000354722 | ENSP00000377865 | eukaryotic translation initiation factor 1A, Y-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity) | ribosomal protein L23 | 0.674 |
EIF1AY | UBC | ENSP00000354722 | ENSP00000344818 | eukaryotic translation initiation factor 1A, Y-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity) | ubiquitin C | 0.880 |
ICT1 | UBC | ENSP00000301585 | ENSP00000344818 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | ubiquitin C | 0.532 |
KCTD9 | UBC | ENSP00000221200 | ENSP00000344818 | potassium channel tetramerisation domain containing 9 | ubiquitin C | 0.721 |
MALSU1 | CALM2 | ENSP00000419370 | ENSP00000272298 | mitochondrial assembly of ribosomal large subunit 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome | calmodulin 2 (phosphorylase kinase, delta) | 0.436 |
MALSU1 | DCTD | ENSP00000419370 | ENSP00000349576 | mitochondrial assembly of ribosomal large subunit 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome | dCMP deaminase; Supplies the nucleotide substrate for thymidylate synthetase | 0.608 |
MALSU1 | UBC | ENSP00000419370 | ENSP00000344818 | mitochondrial assembly of ribosomal large subunit 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome | ubiquitin C | 0.483 |
PHB2 | UBC | ENSP00000441875 | ENSP00000344818 | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | ubiquitin C | 0.988 |
RPL23 | EIF1AX | ENSP00000377865 | ENSP00000368927 | ribosomal protein L23 | eukaryotic translation initiation factor 1A, X-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits | 0.966 |
RPL23 | EIF1AY | ENSP00000377865 | ENSP00000354722 | ribosomal protein L23 | eukaryotic translation initiation factor 1A, Y-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity) | 0.674 |
RPL23 | UBC | ENSP00000377865 | ENSP00000344818 | ribosomal protein L23 | ubiquitin C | 0.995 |
UBC | CALM2 | ENSP00000344818 | ENSP00000272298 | ubiquitin C | calmodulin 2 (phosphorylase kinase, delta) | 0.978 |
UBC | CHMP2B | ENSP00000344818 | ENSP00000263780 | ubiquitin C | charged multivesicular body protein 2B; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] | 0.946 |